To the Editors: Sleep apnoea in Asians and Caucasians: comparing apples and oranges

Genta, Pedro Rodrigues; Lorenzi-Filho, Geraldo

doi:10.1183/09031936.00200510

Cited by 6 publications

(6 citation statements)

References 5 publications

(10 reference statements)

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“…26 Asians have proportionally more fat for a similar BMI level and are at increased cardiovascular risk at lower BMI levels as compared with Caucasians. 27 Findings from our study suggest that, in working Japanese men, short sleep duration is associated not only with Values are means ± s.d. a P for trend values were based on linear regression analyses with ordinal numbers 0 to 3 assigned to lowest through highest categories of sleep duration.…”

Section: Discussionmentioning

confidence: 65%

Short sleep duration in association with CT-scanned abdominal fat areas: the Hitachi Health Study

Nakagawa

Yamamoto

et al. 2012

Int J Obes

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Section: Discussionmentioning

confidence: 65%

Short sleep duration in association with CT-scanned abdominal fat areas: the Hitachi Health Study

Nakagawa

Yamamoto

et al. 2012

Int J Obes

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“…Ethnic differences may play an important role in the discrepancy as well, due to different etiology in the onset of obesity-related morbidities, such as type 2 diabetes. 51 Asians may have a different susceptibility to OSA 52, 53 and a different leptin profile to Caucasians and other ethnicities. 54, 55 Many studies reporting effects of OSA on leptin levels have been performed in relatively lean Asians 7, 9, 14, 15, 19, 20, 24 , while only two studies in Asians have shown no relationship between leptin levels and OSA.…”

Section: Discussionmentioning

confidence: 99%

The role of obesity, different fat compartments and sleep apnea severity in circulating leptin levels: the Icelandic Sleep Apnea Cohort study

et al. 2012

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ObjectivesTo assess whether sleep apnea severity has an independent relationship with leptin levels in blood after adjusting for different measures of obesity and whether the relationship between OSA severity and leptin levels differs depending on obesity level.MethodsCross-sectional study of 452 untreated obstructive sleep apnea (OSA) patients (377 males and 75 females), in the Icelandic Sleep Apnea Cohort (ISAC), age 54.3±10.6 (mean±SD), BMI 32.7±5.3 kg/m2 and apnea-hypopnea index (AHI) 40.2 ± 16.1 events/hour. A sleep study and magnetic resonance imaging of abdominal visceral and subcutaneous fat volume were performed as well as fasting serum morning leptin levels measured.ResultsLeptin levels were more highly correlated with body mass index (BMI), total abdominal and subcutaneous fat volume than visceral fat volume per se. No relationship was found between sleep apnea severity and leptin levels, assessed within three BMI groups (BMI<30, BMI 30–35 and BMI>35 kg/m2). In a multiple linear regression model, adjusted for gender, BMI explained 38.7% of the variance in leptin levels, gender explained 21.2% but OSA severity did not have a significant role and no interaction was found between OSA severity and BMI on leptin levels. However, hypertension had a significant effect on the interaction between OSA severity and obesity (p=0.04). In post-hoc analysis for nonhypertensive OSA subjects (n=249), the association between leptin levels and OSA severity explained a minor but significant variance (3.2%) in leptin levels. This relationship was greatest for nonobese nonhypertensive subjects (significant interaction with obesity level). No relationship of OSA severity and leptin levels was found for hypertensive subjects (n=199).ConclusionObesity and gender are the dominant determinants of leptin levels. OSA severity is not related to leptin levels except to a minor degree in nonhypertensive nonobese OSA subjects.

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“…One study compared a mixed group of OSA males and females with a female-only control group. 38 Furthermore, there are potential differences due to different ethnicities in different studies, as Asians show markedly different etiology in the onset of obesity-related morbidities such as type 2 diabetes compared with Caucasians, 54,55 and they may have a different susceptibility to OSA 56,57 and a different proinflammatory profile to Caucasians and African Americans. 58 These contradictory findings in the earlier literature indicate the likely heterogeneity in the inflammatory response in patients with OSA and the need to address specifically whether obesity levels and the presence of comorbidities influence how OSA affects CRP and IL-6 levels.…”

Section: The Role Of Sleep Disordered Breathingmentioning

confidence: 99%

The Interaction of Obstructive Sleep Apnea and Obesity on the Inflammatory Markers C-Reactive Protein and Interleukin-6: The Icelandic Sleep Apnea Cohort

Arnardóttir

Maislin

Schwab

et al. 2012

Sleep

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To the Editors: Sleep apnoea in Asians and Caucasians: comparing apples and oranges

Cited by 6 publications

References 5 publications

Short sleep duration in association with CT-scanned abdominal fat areas: the Hitachi Health Study

Short sleep duration in association with CT-scanned abdominal fat areas: the Hitachi Health Study

The role of obesity, different fat compartments and sleep apnea severity in circulating leptin levels: the Icelandic Sleep Apnea Cohort study

The Interaction of Obstructive Sleep Apnea and Obesity on the Inflammatory Markers C-Reactive Protein and Interleukin-6: The Icelandic Sleep Apnea Cohort

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