To evaluate the creatinine clearance and compare nephrotoxic potential of Amikacin and Gentamicin, in post operative patients with normal baseline renal function

Bajracharya, Subarna; Pandey, Krishna; Haque, Ataul

doi:10.18203/2319-2003.ijbcp20163216

Cited by 2 publications

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“…Bajracharya et al in a study compared nephrotoxic effect of amikacin and gentamicin throughout creatinine clearance test, in post-operative patients with normal renal function. They found that although the dose of administered gentamicin is much lower than amikacin, gentamicin has a greater nephrotoxic effect (9), but this study found that nephrotoxic effect of these drugs were equal in the 2 groups. Sweileh et al in their study investigated the nephrotoxic effect of gentamicin and amikacin.…”

Section: Discussioncontrasting

confidence: 69%

Nephrotoxic Effect of Gentamicin and Amikacin in Neonates with Infection

et al. 2018

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Background: Infection and its treatment as a common problem in children may induce different complications. Ampicillin and aminoglycosides, as choice drugs for this condition, may have many important side effects, such as nephrotoxic side effects. Therefore, the aim of this study was to evaluate the nephrotoxic effect of gentamicin and amikacin in neonates with infection. Methods: This clinical trial and double blind study was conducted on 80 children with aminoglycosides addministration. Initially, during hospital admission, serum and urine samples were collected for diagnosis of infection. Children based on their treatment were divided to 2 groups, 40 children were treated by ampicillin and amikacin and 40 children were treated by ampicillin and gentamicin, during a 7-day period. At the end of the treatment period, serum and urine samples were taken for measurment of laboratory variables, and GFR, for evaluation of kidney function. Results: Blood Urea Nitrogen (BUN), creatinine and GFR before and after treatment in the two groups did not have statistically significant differences (P > 0.05). In addition age, gender, birth age, infection type, occupation, and education of parents and milk type were equal in the 2 groups. Conclusions: Based on the present study, there were no significant differences between nephrotoxic effect of gentamicin and amikacin in the two groups.

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Section: Discussioncontrasting

confidence: 69%

Nephrotoxic Effect of Gentamicin and Amikacin in Neonates with Infection

et al. 2018

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Impact of Therapeutic Drug Monitoring on Once-Daily Regimen of Amikacin in Patients With Urinary Tract Infection: A Prospective Observational Study

Jayakumar¹,

Mathaiyan²,

Mandal

et al. 2020

Therapeutic Drug Monitoring

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Background: Amikacin is a semisynthetic antibiotic used in the treatment of gram-negative bacterial infections and has a narrow therapeutic index. Although therapeutic drug monitoring is recommended for amikacin, it is not routinely performed because of the use of a less toxic once-daily regimen. Only few studies have evaluated the role of therapeutic drug monitoring in patients treated with amikacin. The objective of our study was to find an association between the pharmacokinetic parameters of amikacin and the time required for a clinical cure, creatinine clearance, and frequency of ototoxicity in patients with urinary tract infection treated for 7 or more days. Methods: A prospective study was conducted on patients with urinary tract infections who were administered amikacin for 7 or more days. Blood samples were obtained from the patients to measure the maximum drug concentration (Cmax) and trough concentration (Ctrough). Minimum inhibitory concentration (MIC) values were determined for patients with positive urine cultures. Serum creatinine levels were estimated every 3 days. The auditory assessment was performed using pure tone audiometry at baseline and weekly until the patients were discharged. Levels of amikacin were analyzed using a validated liquid chromatography-tandem mass spectrometry method. Results: Of 125 patients analyzed, the median time required for a clinical cure was less in the group of patients who achieved a Cmax/MIC ratio ≥8 than it was in those who did not achieve this level [7 versus 8 days (P = 0.02)]. The Ctrough of amikacin was associated with the change in serum creatinine level (P = 0.01) and the incidence of nephrotoxicity (P = 0.004). Conclusions: In patients receiving short-term amikacin therapy, Cmax/MIC value can be used to predict the time required for a clinical cure. Ctrough can be used to predict the occurrence of nephrotoxicity in patients receiving amikacin therapy.

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To evaluate the creatinine clearance and compare nephrotoxic potential of Amikacin and Gentamicin, in post operative patients with normal baseline renal function

Cited by 2 publications

References 0 publications

Nephrotoxic Effect of Gentamicin and Amikacin in Neonates with Infection

Nephrotoxic Effect of Gentamicin and Amikacin in Neonates with Infection

Impact of Therapeutic Drug Monitoring on Once-Daily Regimen of Amikacin in Patients With Urinary Tract Infection: A Prospective Observational Study

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