To be or not to be: orb, the fusome and oocyte specification in Drosophila
Justinn Barr,
Rocky Diegmiller,
Megan M Colonnetta
et al.
Abstract:In the fruit fly Drosophila melanogaster, two cells in a cyst of 16 interconnected cells have the potential to become the oocyte, but only one of these will assume an oocyte fate as the cysts transition through regions 2a and 2b of the germarium. The mechanism of specification depends on a polarized microtubule network, a dynein dependent Egl:BicD mRNA cargo complex, a special membranous structure called the fusome and its associated proteins, and the translational regulator orb. In this work, we have investig… Show more
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