Abstract:SARS–CoV–2–specific CD4+ T cells are likely important in immunity against COVID–19, but our understanding of CD4+ longitudinal dynamics following infection, and specific features that correlate with the maintenance of neutralizing antibodies, remains limited. We characterized SARS–CoV–2–specific CD4+ T cells in a longitudinal cohort of 109 COVID–19 outpatients. The quality of the SARS–CoV–2–specific CD4+ response shifted from cells producing IFNγ to TNFα from five days to four months post–enrollment, with IFNγ… Show more
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