2014
DOI: 10.4049/jimmunol.1302384
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Abstract: The endosomal innate receptor CD158d (KIR2DL4) induces cellular senescence in human NK cells in response to soluble ligand (HLA-G or agonist antibody). These senescent NK cells display a senescence-associated secretory phenotype (SASP) and their secretome promotes vascular remodeling and angiogenesis. To understand how CD158d initiates signaling for a senescence response, we mapped the region in its cytoplasmic tail that controls signaling. We identified a conserved TRAF6 binding motif, which was required for … Show more

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Cited by 11 publications
(9 citation statements)
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References 28 publications
(45 reference statements)
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“…The arrest of cell proliferation caused by an increase in the expression of cell cycle inhibitors, such as p16INK4a, p21WAF1, and p53, is a typical alteration encountered both in senescent immune and non-immune cells of mice and humans. For instance, these changes are present in senescent T cells [ 49 51 ], B cells [ 31 ], NK cells [ 52 ], and macrophages [ 53 55 ]. Cell cycle arrest is commonly associated with the increased expression of senescence-associated β-galactosidase (SA-β-gal) and heterochromatin foci (SAHF) [ 52 54 , 56 , 57 ] as well as the shortening of telomeres [ 58 – 60 ].…”
Section: Hallmarks Of Immunosenescencementioning
confidence: 99%
“…The arrest of cell proliferation caused by an increase in the expression of cell cycle inhibitors, such as p16INK4a, p21WAF1, and p53, is a typical alteration encountered both in senescent immune and non-immune cells of mice and humans. For instance, these changes are present in senescent T cells [ 49 51 ], B cells [ 31 ], NK cells [ 52 ], and macrophages [ 53 55 ]. Cell cycle arrest is commonly associated with the increased expression of senescence-associated β-galactosidase (SA-β-gal) and heterochromatin foci (SAHF) [ 52 54 , 56 , 57 ] as well as the shortening of telomeres [ 58 – 60 ].…”
Section: Hallmarks Of Immunosenescencementioning
confidence: 99%
“…This senescence occurs upon activation of the NK receptor, CD158d, by the soluble HLA‐G, a nonclassical major histocompatibility complex molecule, secreted by fetal trophoblasts. In turn, senescent NK cells produce a specific SASP that positively regulates the neo‐angiogenesis required for embryo implantation during the first trimester of pregnancy (Rajagopalan & Long, 2012; Rajagopalan et al ., 2014). These findings highlight a positive role of cellular senescence in a physiological immune context and open new perspectives in the NK field.…”
Section: Cellular Senescence and Immune Cell Fate Decisionmentioning
confidence: 99%
“…Its association with TNF-receptor-associated factor 6 results in phosphorylation of the kinase TAK1 and links it to nuclear factor kappa B activation pathways. 50 The ubiquitin ligase TNF-receptor-associated factor 6 is known to couple proximal signals from endosomal receptors, such as the Toll-like receptors, through TAK1 for nuclear factor kappa B-dependent pro-inflammatory responses. In this way, KIR2DL4 activates nuclear factor kappa B responses via the canonical pathway to generate pro-inflammatory/pro-angiogenic signals.…”
Section: Kir2dl4-hla-g Interactions and Endosomal Signalingmentioning
confidence: 99%