volume 9, issue 11, P2411-2435 2017
DOI: 10.18632/aging.101328
View full text
|
Sign up to set email alerts
|
Share

Abstract: Cellular senescence is a cell fate program that entails essentially irreversible proliferative arrest in response to damage signals. Tumor necrosis factor-alpha (TNFα), an important pro-inflammatory cytokine secreted by some types of senescent cells, can induce senescence in mouse and human cells. However, downstream signaling pathways linking TNFα-related inflammation to senescence are not fully characterized. Using human umbilical vein endothelial cells (HUVECs) as a model, we show that TNFα induces permanen…

Expand abstract

Search citation statements

Order By: Relevance

Citation Types

1
37
1
1

Paper Sections

0
0
0
0
0

Publication Types

0
0
0
0

Relationship

0
0

Authors

Journals