2021
DOI: 10.3390/biomedicines9080876
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Abstract: Triple-negative breast cancer (TNBC) is a heterogeneous, recurring cancer associated with a high rate of metastasis, poor prognosis, and lack of therapeutic targets. Although target-based therapeutic options are approved for other cancers, only limited therapeutic options are available for TNBC. Cell signaling and receptor-specific targets are reportedly effective in patients with TNBC under specific clinical conditions. However, most of these cancers are unresponsive, and there is a requirement for more effec… Show more

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Cited by 41 publications
(28 citation statements)
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“…BRCA1 plays an important role in cell cycle regulation and SSB; BRCA2 mediates the important recombination enzyme RAD51 and regulates DNA repair mechanisms, as shown in Figure 3 [ 29 , 30 ]. BRCA1 mutations are linked to TNBC and BRCA2 mutations are associated with ER/PR-positive tumors [ 3 , 16 ]. DNA damage repair is associated with the HRR pathway and accomplished by MRE11 , RAD50 , and Exo1 (MRN complex).…”
Section: Mechanism Of Poly (Adp-ribose) Polymerase Inhibitionmentioning
confidence: 99%
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“…BRCA1 plays an important role in cell cycle regulation and SSB; BRCA2 mediates the important recombination enzyme RAD51 and regulates DNA repair mechanisms, as shown in Figure 3 [ 29 , 30 ]. BRCA1 mutations are linked to TNBC and BRCA2 mutations are associated with ER/PR-positive tumors [ 3 , 16 ]. DNA damage repair is associated with the HRR pathway and accomplished by MRE11 , RAD50 , and Exo1 (MRN complex).…”
Section: Mechanism Of Poly (Adp-ribose) Polymerase Inhibitionmentioning
confidence: 99%
“…In response to DNA damage, PARylation occurs [ 31 , 34 ], and RNAi-mediated depletion of PARP1 encourages the destruction of BRCA1/2 -lacking tumor cells [ 16 ]. PARPi treatment displays antitumor effects in patients with BRCA1/2 mutations [ 3 , 16 ]. Approximately 10–20% mutations have been observed in TNBC patients [ 2 , 3 ].…”
Section: Mechanism Of Poly (Adp-ribose) Polymerase Inhibitionmentioning
confidence: 99%
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