Biochemical Pharmacology volume 77, issue 3, P464-471 2009 DOI: 10.1016/j.bcp.2008.10.029 View full text
Madhusudana R. Chaluvadi, Beatrice A. Nyagode, Ryan D. Kinloch, Edward T. Morgan

Abstract: The transcription and protein expression of many cytochrome P450 (P450) genes are down-regulated in animal models of inflammation and infection. We determined previously that hepatic P450 mRNAs are selectively regulated in a mouse model of enteropathogenic bacterial infection, and that this regulation was not dependent on the lipopolysaccharide (LPS) receptor protein toll-like receptor 4 (TLR4). In the dextran sulfate sodium (DSS) model of chemically-induced inflammatory bowel disease (IBD), the reduction in …

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