2011
DOI: 10.1016/j.toxicon.2011.04.017
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Abstract: Scorpion envenomation induces a systemic immune response, and neurotoxins of venom act on specific ion channels, modulating neurotransmitter release or activity. However, little is known about the immunomodulatory effects of crude venom from scorpion Tityus serrulatus (TsV) or its toxins (Ts1, Ts2 and Ts6) in combination with lipopolysaccharide (LPS). To investigate the immunomodulatory effects of TsV and its toxins (Ts1, Ts2 and Ts6), J774.1 cells were stimulated with different concentrations (25, 50 and 100 … Show more

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Cited by 72 publications
(66 citation statements)
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“…TsV and its toxins Ts1 and Ts6 stimulated the production of NO, IL-6, and TNF-a in a macrophage cell line (J774.1), which were enhanced under lipopolysaccharide co-stimulation. However, in the presence of lipopolysaccharide, Ts2 toxin inhibited NO, IL-6, and TNF-a production and stimulated alone the production of IL-10, suggesting an anti-inflammatory activity by this toxin (Zoccal et al 2011).…”
Section: Anti-inflammatory Cytokinesmentioning
confidence: 90%
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“…TsV and its toxins Ts1 and Ts6 stimulated the production of NO, IL-6, and TNF-a in a macrophage cell line (J774.1), which were enhanced under lipopolysaccharide co-stimulation. However, in the presence of lipopolysaccharide, Ts2 toxin inhibited NO, IL-6, and TNF-a production and stimulated alone the production of IL-10, suggesting an anti-inflammatory activity by this toxin (Zoccal et al 2011).…”
Section: Anti-inflammatory Cytokinesmentioning
confidence: 90%
“…Interleukin-6 (IL-6) level was also increased after accidental or experimental SE, and it was positively correlated with the production of acute phase reactant proteins including a1-antitrypsin (a1-AT) (Meki and Mohey El-Dean 1998;Magalhães et al 1999;Fukuhara et al 2003;Petricevich and Peña 2002;HammoudiTriki et al 2004;Adi-Bessalem et al 2008;Zoccal et al 2011). This cytokine exerts its effects on multiple cell types and can stimulate the liver to secrete acute phase proteins, activate B lymphocytes Toxinology DOI 10.1007/978-94-007-6647-1_3- to produce immunoglobulin, promote neutrophil mobilization from the bone marrow, and in concert with IL-1 causes T cell activation.…”
Section: Pro-inflammatory Cytokines and Chemokinesmentioning
confidence: 99%
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“…Recentemente, outro grupo de pesquisadores realizou experimentos demonstrando que a Ts6 estimula a liberação de NO, IL-6 e TNF-α por macrófagos J7774.1 (Zoccal et al, 2011).…”
Section: Tityus Serrulatus Específicas Para Canais Para Potássiounclassified