Titanium dental implants surface-immobilized with gold nanoparticles as osteoinductive agents for rapid osseointegration

Heo, Dong Nyoung; Ko, Wan‐Kyu; Lee, Hak Rae; Lee, Sang Jin; Lee, Dong-Hyun; Um, Soong Ho; Lee, Jung Haeng; Woo, Yi-Hyung; Zhang, Lijie Grace; Lee, Deok-Won

doi:10.1016/j.jcis.2016.02.022

Cited by 96 publications

(53 citation statements)

References 37 publications

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“…It was found that all components showed no significant cytotoxic effects up to 48 h. On the contrary, GNPs and RGNPs exhibited a slight positive effect on ADSCs proliferation where the cell viability increased at a dose-dependent manner after 48 h. It was reported that the surface ligand of the GNPs have an important influence on the cytotoxicity. 29–31, 37 In this study, we used two kinds of GNPs covered with citrate and RGD, and they showed no cytotoxicity and even more enhanced cell proliferation. Therefore, this result indicates that the prepared RGNPs could be useful as a biocompatible osteo-inductive agent.…”

Section: Resultsmentioning

confidence: 99%

“…29 The GNP solution was used without further purification in all experiments. To prepare RGD-conjugated GNPs, Tween 20 solution (1 mM, 500 μl) was first added into 5 mL of GNPs solution obtained from the previous step and then the mixture was stirred for 10 min.…”

Section: Methodsmentioning

confidence: 99%

“…28 In particular, GNPs are the most efficient carrier in the field of bone tissue regeneration because of their effects on the bone remodeling process by enhancing osteogenic differentiation while inhibiting osteoclast activity. 29–34 …”

Section: Introductionmentioning

confidence: 99%

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Enhanced bone tissue regeneration using a 3D printed microstructure incorporated with a hybrid nano hydrogel

et al. 2017

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Three-dimensional (3D) functional constructs with biomimetic mechanical and chemical properties are ideal for various regenerative medicine applications. Within a 3D fabricated construct these properties are intrinsic characteristics of the materials and fabrication method. In this respect, the current use of hydrogels for musculoskeletal tissue repair are not perfect due to the lack of suitable mechanical properties, as well as the high biomimetic requirement for success. To overcome this limitation, we developed a novel functionalized hydrogel with bioactive gold nanoparticles (GNPs) and reinforcing 3D printed microstructure via fused deposition modeling (FDM) for bone tissue regeneration. We used the biodegradable thermoplastic polylactic acid (PLA) as the 3D printed microstructure in combination with photo-curable gelatin hydrogels as the encapsulation matrix for the incorporation of cyclicRGD conjugated GNPs (RGNP), and investigated their mechanical properties. In addition, human adipose-derived stem cells (ADSCs) were encapsulated within the gelatin hydrogel and examined for viability, morphology, and osteogenic differentiation in vitro. The results showed that the stiffness of the composite hydrogel with reinforcing 3D printed microstructure can be readily modulated to simulate the stiffness of the human mandibular condyle. ADSCs encapsulated in the composite structures remained viable within the hydrogel and showed excellent spreading on the 3D printed PLA microstructure. More importantly, osteogenic differentiation with incorporated RGNP promoted significantly higher gene expression of osteogenic specific factors. Therefore, reinforced composite hydrogels are suitable for stem cell differentiation control and bone tissue regeneration.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Enhanced bone tissue regeneration using a 3D printed microstructure incorporated with a hybrid nano hydrogel

et al. 2017

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“…It provides another strategy to compose novel scaffolds for dental stem cells. And Heo et al found that gold nanoparticles (GNPs) coated titanium could enhance the osteogenic differentiation in human adipose-derived stem cells (Heo et al, 2016). What's more, nano-thin polymeric shells constructed and modified by nanostructure involvement were used to immobilize the DPSCs with a layer-by-layer technique to ensure the layers stability and integrity as well as separation from bacterial cells (Grzeczkowicz et al, 2015).…”

Section: Perspectivesmentioning

confidence: 99%

Application of Stem Cells in Oral Disease Therapy: Progresses and Perspectives

Yang¹,

Qiu²,

Zhou³

et al. 2017

Front. Physiol.

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Stem cells are undifferentiated and pluripotent cells that can differentiate into specialized cells with a more specific function. Stem cell therapies become preferred methods for the treatment of multiple diseases. Oral and maxillofacial defect is one kind of the diseases that could be most possibly cured by stem cell therapies. Here we discussed oral diseases, oral adult stem cells, iPS cells, and the progresses/challenges/perspectives of application of stem cells for oral disease treatment.

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“…These properties incorporate the microstructure of the implant material and make it biocompatible with tensile strength, quality, consumption, wear and crack resistance [1]. The materials that are used in the implants are fabricated structure or their natural properties they elicit when implanted [2]. The clinical survival rates for platinum implants and its medicinal purpose have made it the best quality material for creation of implants.…”

Section: Introductionmentioning

confidence: 99%

Impact of Titanium Nanoparticles in Implants

Narendhran¹

2017

RDMS

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Bone imbed mistreatment metal plates are being improved to meet speedier osseointegration and an additional grounded bone insert interface. The goal of this summary is to offer a broad information regarding the pharmacological medicine examination of bone imbed mistreatment metal (Ti) nanoparticles. The going with paper essentially focuses on the parlous impacts of implant material and also the effect of their physical and compound properties on the treatment result. In spite of the means that metal remains the quality biomaterial for a protracted time, affectability happens. On these lines the extension within the metal concentrations that are gotten from the inserts could cause extreme or long material medical effects. In clinical examinations it's found that 0.6% of 1500 patient show metal ominously helpless reactions. Afterward, support in vitro and particularly organized in vivo clinical examinations and specific experiences are needed whereas overseeing metal installs in people to constrain the speed of material medical effects.

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Titanium dental implants surface-immobilized with gold nanoparticles as osteoinductive agents for rapid osseointegration

Cited by 96 publications

References 37 publications

Enhanced bone tissue regeneration using a 3D printed microstructure incorporated with a hybrid nano hydrogel

Enhanced bone tissue regeneration using a 3D printed microstructure incorporated with a hybrid nano hydrogel

Application of Stem Cells in Oral Disease Therapy: Progresses and Perspectives

Impact of Titanium Nanoparticles in Implants

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