Tissue‐spray ionization mass spectrometry for raw herb analysis

Chan, S. C.; Wong, Melody Yee-Man; Tang, Ho-Wai; Che, Chi‐Ming; Ng, Kwan‐Ming

doi:10.1002/rcm.5177

Cited by 60 publications

(41 citation statements)

References 24 publications

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“…Leaf spray also be used for in situ chemical analysis of raw herbs [53], and distinction of coffee origin [54], phytochemicals in petals [55], and Chinese and Japanese star anise [56].…”

Section: Leaf Spraymentioning

confidence: 99%

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

2016

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Paper spray mass spectrometry (MS) is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma, and urine spots at the low ng/mL to pg/mL levels without sample preparation. No front end separation is performed, so tandem mass spectrometry (MS/MS) or high resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique, and discuss some of its limitations. _________________________________________________________________________________ AbstractPaper spray mass spectrometry (MS) is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma, and urine spots at the low ng/mL to pg/mL levels without sample preparation. No front end separation is performed, so tandem mass spectrometry (MS/MS) or high resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique, and discuss some of its limitations.

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“…Leaf spray also be used for in situ chemical analysis of raw herbs [53], and distinction of coffee origin [54], phytochemicals in petals [55], and Chinese and Japanese star anise [56].…”

Section: Leaf Spraymentioning

confidence: 99%

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

2016

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“…Use of noncapillary emitters avoids the problem of clogging that could occur in capillary-based ESI and allows much easier sampling. Particularly, analysis of samples on surfaces or in difficult-to-access corners could be greatly facilitated by collecting sample using paper [12,13] or wooden tips [14] followed by paper spray or wooden tip ESI-MS. More recently, noncapillary ESI techniques have been further extended to direct mass spectrometric analysis of biological tissue [15][16][17][18].…”

Section: E Lectrospray Ionization (Esi) Is a Powerful Massmentioning

confidence: 99%

Analytical Properties of Solid-substrate Electrospray Ionization Mass Spectrometry

Yao

2012

J. Am. Soc. Mass Spectrom.

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Abstract. Conventional electrospray ionization mass spectrometry (ESI-MS) uses a capillary for sample loading and ionization. Along with the development of ambient ionization techniques, ESI-MS using noncapillary emitters has attracted more interest in recent years. Following our recent report on ESI-MS using wooden tips (Anal. Chem. 83, 8201-8207 (2011)), the technique was further investigated and extended in this study. Our results revealed that the wooden tips could serve as a chromatographic column for separation of sample components. Sequential and exhaustive ionization was observed for proteins and salts on wooden tips with salts ionized sooner and proteins later. Nonconductive materials that contain microchannels/pores could be used as tips for ESI-MS analysis with sample solutions loaded to the sharp-ends only, since rapid diffusion of sample solutions by capillary action would enable the tips to become conductive. Tips of inert materials such as bamboo, fabrics, and sponge could be used for sample loading and ionization, while samples such as tissue, mushroom, and bone could form tips to induce ionization for direct analysis with application of a high voltage.

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“…Di erent kinds of plant tissues, including leaf, root, stem, fruit and rhizome, and animal tissues, including heart, lung, liver, kidney, spleen and medulla, have been analyzed and various compounds such as lipids, alkaloids, glucosides, lignans, pharmaceuticals and proteins could be detected. 47) Similar techniques, termed as tissue-spray 48) and leaf spray, 49) were also coherently developed for direct analysis of plant tissues by two other research groups. ese techniques have recently been successfully applied for detection of allergenic urushoils directly from poisonous ivy leaves, 50) determination of pesticides in peel and pulp of di erent fruits and vegetables, 51) and di erentiation of Chinese and Japanese star anises based on their di erences in anisatin content.…”

Section: Direct Ionization (Di) Of Solid Sam-plesmentioning

confidence: 99%

Electrospray Ionization on Solid Substrates

Yao

2014

Mass Spectrometry

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Development of electrospray ionization on solid substrates (solid-substrate ESI) avoids the clogging problem encountered in conventional capillary-based ESI, allows more convenient sampling and permits new applications. So far, solid-substrate ESI with various materials, e.g., metals, paper, wood, bers and biological tissue, has been developed, and applications ranging from analysis of pure compounds to complex mixtures as well as in vivo study were demonstrated. Particularly, the capability of solid-substrate ESI in direct analysis of complex samples, e.g., biological uids and foods, has signi cantly facilitated mass spectrometric analysis in real-life applications and led to increasingly important roles of these techniques nowadays. In this review, various solid-substrate ESI techniques and their applications are summarized and the prospects in this eld are discussed.Please cite this article as: P.-K. So, et al., Electrospray Ionization on Solid Substrates, Mass Spectrom (Tokyo) 2014; 3(2): S0028;

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Tissue‐spray ionization mass spectrometry for raw herb analysis

Cited by 60 publications

References 24 publications

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

Analytical Properties of Solid-substrate Electrospray Ionization Mass Spectrometry

Electrospray Ionization on Solid Substrates

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