Joanne Boldison, Colin J. Chu, David A. Copland, Philippa J. P. Lait, Tarnjit K. Khera, Andrew D. Dick, Lindsay B. Nicholson
Abstract:Experimental autoimmune uveoretinitis is a model for noninfectious posterior segment intraocular inflammation in humans. Although this disease is CD4+ T cell dependent, in the persistent phase of disease CD8+ T cells accumulate. We show that these are effector memory CD8+ T cells that differ from their splenic counterparts with respect to surface expression of CD69, CD103, and Ly6C. These retinal effector memory CD8+ T cells have limited cytotoxic effector function, are impaired in their ability to proliferate…
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