Tissue oxygen exchange and oxidative processes in long-livers: Age-related peculiarities

Korkushko, O. V.; Иванов, Л. А.; Shatilo, V. B.

doi:10.1134/s2079057013010074

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…In previous studies conducted with patients with CVDs, Korkushko et al . [ 78 ] investigated the efficacy of exercise training under hypoxia in the elderly with CAD, and they confirmed that hypoxic training is a non-pharmacological therapy that can effectively improve CAD through the economic function of the cardiovascular system, optimization of oxygen consumption, improvement of vasomotor endothelial function due to increased NO formation, and normalization of microcirculation. Serevrovskaya and Xi [ 24 ] conducted a review study on the practical effectiveness of exercise intervention under hypoxia as a non-pharmacological treatment for CVDs by synthesizing several studies.…”

Section: Hypoxic Therapy and Clinical Implicationsmentioning

confidence: 99%

“…In summary, hypoxic therapy, such as acute exercise and/or exercise intervention under hypoxia, induces greater reductions in BP and improves vascular endothelial function and hemorheological properties, thereby reducing cardiovascular risk and improving various aspects of cardiovascular function compared to circumstances under normoxia [ 24 , 33 , 36 , 37 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 75 , 77 , 78 , 79 ]. This evidence confirms that hypoxic therapy is a promising modality for improving cardiovascular benefits and in preventing and treating CVDs.…”

Section: Hypoxic Therapy and Clinical Implicationsmentioning

confidence: 99%

See 1 more Smart Citation

Hypoxic Therapy as a New Therapeutic Modality for Cardiovascular Benefit: A Mini Review

Park¹,

Kim²,

Jung³

et al. 2022

Rev. Cardiovasc. Med.

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Cardiovascular diseases (CVDs) are recognized as one of the major causes of morbidity and mortality worldwide. Generally, most CVDs can be prevented by addressing behavioral risk factors, including smoking, unhealthy diet and obesity, lack of physical activity, and alcohol abuse. Therefore, it is important to have a healthy lifestyle by performing regular physical activity to improve cardiovascular health and diseases. However, a majority of adults worldwide do not meet the minimum recommendations for regular aerobic exercise, and overweight and obesity ratio continues to rise. In addition, obese individuals, with a high prevalence of CVDs, have a lower participation rate for exercise because of the strain on the musculoskeletal system. Hypoxic therapy, including exposure or exercise intervention under hypoxia, has been utilized as a new therapeutic modality for cardiovascular benefit and amelioration of CVDs. Hypoxic therapy shows various physiological and pathophysiological properties, including increased appetite suppression and dietary intake reduction, increased energy consumption, improved glycogen storage, enhanced fatty acid oxidation, improved myocardial angiogenesis or ventricular remodeling, augmentation of blood flow within the skeletal muscle vascular beds, and reduction of the burden on the musculoskeletal system making it applicable to patients with CVDs and obesity with attenuated cardiovascular function. In particular, hypoxic therapy is very effective in improving cardiovascular benefits and preventing CVDs by enhancing arterial function, vascular endothelial function, and hemorheological properties. These observations indicate that hypoxic therapy may be an important and essential strategy for improving cardiovascular health and reducing cardiovascular morbidity and mortality.

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Section: Hypoxic Therapy and Clinical Implicationsmentioning

confidence: 99%

Section: Hypoxic Therapy and Clinical Implicationsmentioning

confidence: 99%

Hypoxic Therapy as a New Therapeutic Modality for Cardiovascular Benefit: A Mini Review

Park¹,

Kim²,

Jung³

et al. 2022

Rev. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…Drug-resistant tuberculosis, chronic granulomatous disease, osteopetrosis (Donnelly et al, 2009;Miller et al, 2009) IL-2 Malignant melanoma, renal cell carcinoma (Chavez et al, 2009) IL-7 Expansion of T cells in patients with cancer, HIV, or allogeneic transplantation (Sportès et al, 2009) Dexamethasone See Table 7 (ABCC5) Hypoxia (intermittent) a MCI (NCT05495087), enhancement of cognition in older adults (NCT03957213), sleep apnea (Gerst et al, 2001;Yokhana et al, 2012), chronic obstructive pulmonary disease (Serebrovskaya et al, 2003), enhancement of aerobic exercise performance (Fulco et al, 2000;Shatilo et al, 2008), systemic hypertension (Serebrovskaya et al, 2008), coronary artery disease (Korkushko et al, 2010), obesity (NCT02973438), prevention of acute hypoxia injury (during mountain climbing) (NCT05733338, NCT04725539)…”

Section: Ifn-γmentioning

confidence: 99%

Enhancing of cerebral Abeta clearance by modulation of ABC transporter expression: a review of experimental approaches

Loeffler

2024

Front. Aging Neurosci.

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Clearance of amyloid-beta (Aβ) from the brain is impaired in both early-onset and late-onset Alzheimer’s disease (AD). Mechanisms for clearing cerebral Aβ include proteolytic degradation, antibody-mediated clearance, blood brain barrier and blood cerebrospinal fluid barrier efflux, glymphatic drainage, and perivascular drainage. ATP-binding cassette (ABC) transporters are membrane efflux pumps driven by ATP hydrolysis. Their functions include maintenance of brain homeostasis by removing toxic peptides and compounds, and transport of bioactive molecules including cholesterol. Some ABC transporters contribute to lowering of cerebral Aβ. Mechanisms suggested for ABC transporter-mediated lowering of brain Aβ, in addition to exporting of Aβ across the blood brain and blood cerebrospinal fluid barriers, include apolipoprotein E lipidation, microglial activation, decreased amyloidogenic processing of amyloid precursor protein, and restricting the entrance of Aβ into the brain. The ABC transporter superfamily in humans includes 49 proteins, eight of which have been suggested to reduce cerebral Aβ levels. This review discusses experimental approaches for increasing the expression of these ABC transporters, clinical applications of these approaches, changes in the expression and/or activity of these transporters in AD and transgenic mouse models of AD, and findings in the few clinical trials which have examined the effects of these approaches in patients with AD or mild cognitive impairment. The possibility that therapeutic upregulation of ABC transporters which promote clearance of cerebral Aβ may slow the clinical progression of AD merits further consideration.

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“…Interval high-altitude hypoxia has been successfully used to prevent the ischemic necrosis development of the myocardium in rats [26]. A significant protective effect was shown not only in a common laboratory rodent model but also in humans, where the effectiveness of hypoxic training in the treatment of neurocirculatory dystonia patients [27,28], neurodegenerative injuries, cerebrovascular accidents patients, and cerebral palsy patients [29,30,31].…”

Section: Hypoxia and Hypercapnia Is It Opposition Or Synergy?mentioning

confidence: 99%

Neuroprotective effect of hypoxic-hypercapnic training. Review

Tolstun,

Kholin

2023

A&L

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The neuroprotective effects of hypercapnia, especially with hypoxia combined, interested in the context of nerve cells forming protective mechanisms. Hypercapnia not only acts as a potent neuroprotector but also increases tissue tolerance to ischemia and reperfusion. Hypercapnic effects are based on many different mechanisms including energy metabolism modulation, adaptive signaling pathways activation, histological damage reduction, pro-inflammatory factors, angiogenesis activation, and activation of synthetic processes in neurons. The summarized data indicate prospects for further research to better understand the molecular and physiological aspects of neuroprotection during hypercapnia and hypoxia, as well as to determine the conditions under which the best neuroprotective effect is achieved with a subsequent reduction in neurological deficits. __________________________________________________________________________________________ Keywords: hypercapnia, hypoxia, neuroprotection, permissive hypercapnia, ischemia, stroke

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Tissue oxygen exchange and oxidative processes in long-livers: Age-related peculiarities

Cited by 3 publications

References 14 publications

Hypoxic Therapy as a New Therapeutic Modality for Cardiovascular Benefit: A Mini Review

Hypoxic Therapy as a New Therapeutic Modality for Cardiovascular Benefit: A Mini Review

Enhancing of cerebral Abeta clearance by modulation of ABC transporter expression: a review of experimental approaches

Neuroprotective effect of hypoxic-hypercapnic training. Review

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