Tissue factor in plasma of patients with disseminated intravascular coagulation

Takahashi, Hiroyuki; Satoh, Naoaki; Wada, Ken; Takakuwa, Etsuko; Seki, Yoshinobu; Shibata, Akira

doi:10.1002/ajh.2830460414

Cited by 41 publications

(34 citation statements)

References 25 publications

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“…Plasma TF concentration has been reported to be increased in various disease such as disseminated intravascular coagulation (DIC), ischaemic heart disease, antiphospholipid syndrome, and cancer (Koyama et al, 1994;Takahashi et al, 1994;Wada et al, 1994;Suefuji et al, 1997;Cuadrando et al, 1998;Falciani et al, 1998;Misumi et al, 1998). We showed that plasma TF concentration was up-regulated in primary and recurrent breast cancer patients.…”

Section: supporting

confidence: 53%

Tissue factor expression in breast cancer tissues: its correlation with prognosis and plasma concentration

Ueno¹,

Toi²,

et al. 2000

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Tissue factor (TF), an initiator of the extrinsic coagulation cascade, is expressed in a wide range of cancer cells and plays important roles in cancer progression and metastasis. Recently, the intracellular function of TF has been revealed to be involved in cancer invasion, independent of the blood coagulation pathway. To evaluate the clinical significance of TF expression, we performed an enzyme-linked immunosorbent assay (ELISA) in the plasma of 67 breast cancer patients and immunohistochemistry in 213 breast cancer tissues. In the ELISA study, we showed an up-regulation of plasma TF concentration in breast cancer patients compared with normal controls. Immunohistochemistry demonstrated that TF was expressed in tumour cells and stromal cells and tumour TF expression closely correlated with stromal TF expression ( P = 0.0005). The concentration of plasma TF was associated with tissue TF expression in both tumour and stroma. The multivariate analysis demonstrated that tumour TF expression was an independent prognostic indicator for overall survival ( P = 0.0452). Our data show that plasma TF concentration reflects tissue TF expression and tumour TF expression can provide some predictive value for prognosis and distant metastasis, which indicates the importance of TF function in tumour progression. © 2000 Cancer Research Campaign

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Section: supporting

confidence: 53%

Tissue factor expression in breast cancer tissues: its correlation with prognosis and plasma concentration

Ueno¹,

Toi²,

et al. 2000

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“…These studies demonstrated a 2-to 3-fold faster clotting time when adipose tissue extracts from obese mice were compared with those from the lean mice (data not shown). Finally, hypercoagulable states caused by shedding of TF-rich microvesicles from cell surfaces have been demonstrated in cancer (52), dessimionated intravascular coagulation (53,54), collagen disease, diabetic microangiopathy, and chronic renal failure (55). Plasma TF activity was also observed in diabetes mellitus patients, with the concentrations being significantly higher in patients with retinopathy or nephropathy than in patients with no complications (56).…”

Section: Discussionmentioning

confidence: 99%

Tissue factor gene expression in the adipose tissues of obese mice

Samad

Pandey

Loskutoff

1998

Proc. Natl. Acad. Sci. U.S.A.

126

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Altered expression of proteins of the fibrinolytic and coagulation cascades in obesity may contribute to the cardiovascular risk associated with this condition. We previously reported that plasminogen activator inhibitor 1 (PAI-1) is dramatically up-regulated in the plasma and adipose tissues of genetically obese mice. This change may disturb normal hemostatic balance and create a severe hypofibrinolytic state. Here we show that tissue factor (TF) gene expression also is significantly elevated in the epididymal and subcutaneous fat pads from ob͞ob mice compared with their lean counterparts, and that its level of expression in obese mice increases with age and the degree of obesity. Cell fractionation and in situ hybridization analysis of adipose tissues indicate that TF mRNA is increased in adipocytes and in unidentified stromal vascular cells. Transforming growth factor ␤ (TGF-␤) is known to be elevated in the adipose tissue of obese mice, and administration of TGF-␤ increased TF mRNA expression in adipocytes in vivo and in vitro. These observations raise the possibility that TF and TGF-␤ may contribute to the increased cardiovascular disease that accompanies obesity and related non-insulin-dependent diabetes mellitus, and that the adipocyte plays a key role in this process. The recent demonstration that TF also inf luences angiogenesis, cell adhesion, and signaling suggests that its exact role in adipose tissue physiology͞pathology, may be complex.

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“…Recently, controversy has emerged concerning the presence and functionality of TF species circulating in blood. Reports of circulating TF can be divided into those showing TF localized on the surface of blood cells and microparticles and those describing a TF species that circulates as a soluble protein (21)(22)(23)(24)(25)(26)(27). These blood TF species are invoked in support of a new hypothesis that TF-dependent thrombin generation requires a continuous infusion of this cofactor.…”

Section: Tissue Factor (Tf)mentioning

confidence: 99%

The Tissue Factor Requirement in Blood Coagulation

Orfeo

Butenas

Brummel‐Ziedins

et al. 2005

Journal of Biological Chemistry

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Formation of thrombin is triggered when membrane-localized tissue factor (TF) is exposed to blood. In closed models of this process, thrombin formation displays an initiation phase (low rates of thrombin production cause platelet activation and fibrinogen clotting), a propagation phase (>95% of thrombin production occurs), and a termination phase (prothrombin activation ceases and free thrombin is inactivated). A current controversy centers on whether the TF stimulus requires supplementation from a circulating pool of blood TF to sustain an adequate procoagulant response. We have evaluated the requirement for TF during the progress of the blood coagulation reaction and have extended these analyses to assess the requirement for TF during resupply ("flow replacement"). Elimination of TF activity at various times during the initiation phase indicated: a period of absolute dependence (<10 s); a transitional period in which the dependence on TF is partial and decreases as the reaction proceeds (10 -240 s); and a period in which the progress of the reaction is TF independent (>240 s). Resupply of reactions late during the termination phase with fresh reactants, but no TF, yielded immediate bursts of thrombin formation similar in magnitude to the original propagation phases. Our data show that independence from the initial TF stimulus is achieved by the onset of the propagation phase and that the ensemble of coagulation products and intermediates that yield this TF independence maintain their prothrombin activating potential for considerable time. These observations support the hypothesis that the transient, localized expression of TF is sufficient to sustain a TF-independent procoagulant response as long as flow persists. Tissue factor (TF)2 is a 263-amino acid glycoprotein with three major domains: 1) an extracellular domain (residues 1-219) that binds with high affinity to factor VIIa; 2) a transmembrane domain (residues 220 -242) that anchors TF to the membrane surface; and 3) a cytoplasmic domain (residues 243-263) (1-3). Binding of plasma factor VIIa to membrane-bound TF results in an ϳ2 ϫ 10 7 -fold increase in the enzymatic activity of factor VIIa toward its natural substrates factor IX and factor X (4). Most studies have concluded that membrane-bound TF, expressed by inflammatory cells and cells outside the vasculature, are the key initiators of the blood coagulation process (5-7).The generation of thrombin, the enzyme responsible for clot formation as well as other procoagulant and anticoagulant functions during the blood coagulation process occurs in a nonlinear fashion (8). During an initiation phase, tiny amounts of thrombin are generated, platelets, zymogens, and procofactors are activated, and complex enzymes assembled (9, 10). Subsequently, a propagation phase of thrombin generation occurs, characterized by dramatic increases in both the rate of thrombin generation and levels of thrombin. The duration of the initiation phase, which roughly corresponds to the clotting time of blood and plasma, is predomi...

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Tissue factor in plasma of patients with disseminated intravascular coagulation

Cited by 41 publications

References 25 publications

Tissue factor expression in breast cancer tissues: its correlation with prognosis and plasma concentration

Tissue factor expression in breast cancer tissues: its correlation with prognosis and plasma concentration

Tissue factor gene expression in the adipose tissues of obese mice

The Tissue Factor Requirement in Blood Coagulation

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