Tissue factor expression is decreased in monocytes obtained from blood during Mediterranean or high carbohydrate diets

The Effect of Mediterranean Diet on Metabolic Syndrome and its Components

“…In addition, the MD intervention varied between the clinical trials in terms of hours of intervention, detail of the recommendations given, and macronutrient composition of the diet. In most trials, the control diet was a low-fat, high-carbohydrate diet (21,23,24,42,43,46,47,49,53,(55)(56)(57)(58)(59)(60)(61)(62), a low-carbohydrate diet (49,63), a prudent diet (30,32), usual patient treatment (22,64), American Diabetes Association diet (45), receiving general healthy dietary information (27,29,31,39,41), high-saturated-fat diet (30,34,46,47,53,(58)(59)(60)(61), or less counselling on an MD prescription (51). In 9 trials, MD was part of a lifestyle intervention comprising exercise (24,32,43) or a structured plan (smoking cessation, exercise, stress management) (21,22,…”

“…Moreover, 29 clinical trials with 3,822 subjects (2,202 assigned to an MD, and 1,903 assigned to a control diet) examined the effect of adherence to the MD on HDL-cholesterol. Seven studies (31,39,(41)(42)(43)(44)(45) reported a beneficial effect of an MD, as compared with the control diet, whereas 2 studies reported a beneficial effect of a high saturated fat diet as compared with the MD (46,47). Overall, adherence to the MD was associated with higher HDL-cholesterol levels as compared with the control diet ( Data are presented as mean difference between highest versus lowest category of diet score (95% confidence interval).…”

Mediterranean Diet and Cardiovascular Risk

“…The effects of olive oil in haemostasis go beyond platelets, and influences directly the plasma concentration of several procoagulant substances, like FVII Junker et al, 2001a;Junker et al, 2001b;Smith et al, 2003;Temme et al, 1999;Turpeinen & Mutanen, 1999;Williams, 2001), tissue factor (Bravo-Herrera et al, 2004), fibrinogen , PAI-1 factor (Avellone et al, 1998;Perez-Jimenez, 2005;Perez-Jimenez et al, 1999;Perez-Jimenez et al, 2002) or von Willebrand Factor (Perez-Jimenez et al, 1999O. Rasmussen et al, 1994), reducing the thrombogenic state when compared to diets rich in saturated fatty acids.…”

Olive oil and the haemostatic system

“…PUFA inhibits this expression [48,49]. Saturated fats raise levels of TF both post-prandially (by up to 56%) and in their basal values [50], while low-fat diets, like the MUFA-rich MD, lower the activity of TF in circulating monocytes [51].…”