Tissue factor activities of streptozotocin induced diabetic rat tissues and the effect of peanut consumption

Emekli-Alturfan, Ebru; Kasikci, Emel; Yarat, Ayşen

doi:10.1002/dmrr.757

Cited by 27 publications

(25 citation statements)

References 47 publications

(60 reference statements)

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“…19 It could also be the case in our model, since a marked increased level of IL-1β in STZ-induced diabetic rats was observed.…”

Section: Discussionmentioning

confidence: 50%

“…It is necessary to mention that TF is recognised as an essential initiator of thrombin generation and coagulation which may be involved in thrombus propagation at the site of vascular injury. 18,19 The mechanism of TF increase in diabetes may be related to the formation of advanced glycation end products and reactive oxygen species, which activate NFκB leading to TF production. 20 Hyperglycaemia impairs fibrinolytic activity on the surface of endothelial cells and decreases plasma fibrinolytic potential.…”

Section: Discussionmentioning

confidence: 99%

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Eplerenone reduces arterial thrombosis in diabetic rats

Zakrzeska

Gromotowicz-Popławska

Szemraj

et al. 2014

J Renin Angiotensin Aldosterone Syst

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Introduction: Clinical studies demonstrated the benefits of eplerenone (EPL) in reduction of cardiovascular events in diabetic patients. Since acute myocardial infarction (AMI) and stroke are related to acute intravascular thrombosis, we postulate that the beneficial effects of EPL may result from its antithrombotic action. Materials and methods: Streptozotocin (STZ)-induced diabetic rats were treated with EPL (100 mg/kg/day) for 10 days. Thrombosis in the carotid artery was stimulated electrically. Results: Thrombosis development was enhanced in STZ-induced diabetic rats as compared to normoglycaemic controls. EPL caused prolongation of the time to artery occlusion, reduction in the incidence of occlusion and decrease in thrombus weight. Changes in the thrombi structure and the inhibition of hypertrophy of the tunica media in the artery wall were also observed. EPL caused reduction in tissue factor, plasminogen activator inhibitor type 1 and interleukin-1β plasma levels. Conclusions: Our study demonstrated the antithrombotic effect of EPL manifested by a decrease in the dynamics of thrombus formation and changes in its structure. The changes in thrombosis process were accompanied by antihaemostatic, profibrinolytic and anti-inflammatory effects. The aldosterone blockade with EPL seems to be an additional pharmacological strategy for the prevention and treatment of thrombotic disorders in diabetes.

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“…19 It could also be the case in our model, since a marked increased level of IL-1β in STZ-induced diabetic rats was observed.…”

Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Eplerenone reduces arterial thrombosis in diabetic rats

Zakrzeska

Gromotowicz-Popławska

Szemraj

et al. 2014

J Renin Angiotensin Aldosterone Syst

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show abstract

“…Low levels of TF lead to alveolar hemorrhage, potentiating murine acute lung injury and oxidative stress (Bastarache et al, 2012). Emekli-Alturfan et al (2007) indicated a decrease in lung TF activity in STZ-treated rat. A similar result was also obtained in the present study.…”

Section: Discussionmentioning

confidence: 99%

Chard (Beta vulgarisvar.cicla) extract improved hyperglycemia-induced oxidative stress and surfactant-associated protein alterations in rat lungs

Öztay¹,

Saçan

Kayalar³

et al. 2015

Pharmaceutical Biology

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Context: Chard is used as an antidiabetic agent by the diabetic patients in Turkey. Objective: The effect of chard extract [Beta vulgaris L. var. cicla (Chenopodiaceae)] on the antioxidant system and the expression of surfactant-associated proteins (SP) in the lungs of hyperglycemic rats were examined. Materials and methods: Hyperglycemia was induced by a single dose of streptozotocin (60 mg/kg) provided intraperitoneally. Fourteen days after the rats were rendered hyperglycemic, the chard (2 g/kg/d), insulin (6 U/kg/d), and chard plus insulin (as mentioned above) were administered to rats for 45 d. On day 60, rats' lungs were removed. Oxidative stress parameters and SP expression were assayed. Results: The lungs of hyperglycemic rats were characterized by the induced lipid and protein oxidation, elevated myeloperoxidase and xanthine oxidase activities, decreased glutathione levels, and reduced tissue factor and antioxidant enzymes activities (catalase, superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase). Chard treatment alone and chard treatment combined with insulin were capable of achieving a regression of pulmonary oxidative stress, by inhibiting lipid and protein oxidation, and restoring the antioxidant system of hyperglycemic rats. SP-A expressions were significantly unchanged in all groups, whereas pro-SP-C and SP-D expressions were reduced in hyperglycemic rats. Pro-SP-C and SP-D levels were increased by chard and insulin administrations alone and combined in hyperglycemic rats. Discussion and conclusion: All treatments have a positive effect on the surfactant and antioxidant systems of the lungs of hyperglycemic rats. The best therapeutic effect was provided by treatment with chard extract alone in the compensation of hyperglycemic symptoms.

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“…It is not actively found in the blood but it is the cell component of the membranes (48). It has been shown that some tissues and fluids of the body have TF activities (49)(50)(51)(52)(53)(54). Thrombotic and fibrinolytic mechanisms are activated after burn injury, with the extent of activation correlated to the severity of the thermal injury (5).…”

Section: Discussionmentioning

confidence: 99%

The effect of silymarin on the liver in thermal burn injury

Yemişen¹

2014

mpj

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Tissue factor activities of streptozotocin induced diabetic rat tissues and the effect of peanut consumption

Cited by 27 publications

References 47 publications

Eplerenone reduces arterial thrombosis in diabetic rats

Eplerenone reduces arterial thrombosis in diabetic rats

Chard (Beta vulgarisvar.cicla) extract improved hyperglycemia-induced oxidative stress and surfactant-associated protein alterations in rat lungs

The effect of silymarin on the liver in thermal burn injury

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