Tissue expanders; review of indications, results and outcome during 15 years’ experience

Karimi, Hamid; Latifi, Noorahmad; Momeni, Maryam; Maroufi, Shahnam Sedigh; Karimi, Afzal; Akhoondinasab, Mohammad-Reza

doi:10.1016/j.burns.2018.11.017

Cited by 15 publications

(10 citation statements)

References 96 publications

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“…The use of tissue expansion in burn scar excision, implant-based breast reconstruction, scalp defects, nasal reconstruction, and treating other deformities has become increasingly widespread in plastic reconstructive surgery ( Karimi et al, 2019 ). Tissue expansion is a physiological process characterized by the ability of skin to increase its superficial area in response to mechanical stretch.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Profiling Reveals Important Transcription Factors and Biological Processes in Skin Regeneration Mediated by Mechanical Stretch

Liu

Xiong

et al. 2021

Front. Genet.

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Background: Mechanical stretch is utilized to promote skin regeneration during tissue expansion for reconstructive surgery. Although mechanical stretch induces characteristic morphological changes in the skin, the biological processes and molecular mechanisms involved in mechanically induced skin regeneration are not well elucidated.Methods: A male rat scalp expansion model was established and the important biological processes related to mechanical stretch-induced skin regeneration were identified using Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and gene set enrichment analysis (GSEA). Analysis was also conducted by constructing a protein–protein interaction (PPI) network, identifying key modules and hub genes, determining transcription factor (TF)-mRNA regulatory relationships, and confirming the expression pattern of the TFs and hub genes.Results: We identified nine robust hub genes (CXCL1, NEB, ACTN3, MYOZ1, ACTA1, TNNT3, PYGM, AMPD1, and CKM) that may serve as key molecules in skin growth. These genes were determined to be involved in several important biological processes, including keratinocyte differentiation, cytoskeleton reorganization, chemokine signaling pathway, glycogen metabolism, and voltage-gated ion channel activity. The potentially significant pathways, including the glucagon signaling pathway, the Wnt signaling pathway, and cytokine–cytokine receptor interaction, were distinguished. In addition, we identified six TFs (LEF1, TCF7, HMGA1, TFAP2C, FOSL1, and ELF5) and constructed regulatory TF–mRNA interaction networks.Conclusion: This study generated a comprehensive overview of the gene networks underlying mechanically induced skin regeneration. The functions of these key genes and the pathways in which they participate may reveal new aspects of skin regeneration under mechanical strain. Furthermore, the identified TF regulators can be used as potential candidates for clinical therapeutics for skin pretreatment before reconstructive surgery.

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Section: Introductionmentioning

confidence: 99%

Transcriptome Profiling Reveals Important Transcription Factors and Biological Processes in Skin Regeneration Mediated by Mechanical Stretch

Liu

Xiong

et al. 2021

Front. Genet.

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“…A study showed that the re-expansion technique had been widely used in patients without enough normal tissue for coverage of the defects in recent years. It has been shown to be safe and reliable as long as the dermis of the skin is sufficiently thick ( 19 ). Therefore, static expansion was retained for about 1 month to assist in repairing the dermis and resisting contracture after our expander at the anterior thoracic region reached the ideal volume.…”

Section: Discussionmentioning

confidence: 99%

Creating a re-expanded prefabricated island flap constructed with an anastomosed vascular pedicle for burned ear reconstruction: a case report

Chen¹,

Zhang²,

Han³

et al. 2022

Ann Transl Med

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Background: The combined use of various flap techniques has rapidly improved the reconstruction quality of auricle defects that are complicated by a scarcity of periauricular skin after severe burns. Nevertheless, there is still no preferable method when the optimal alternative skin to cover the auricular framework is unavailable and the periauricular vascular network is devastated.Case Description: Copious scars were observed in the periauricular region, neck, forearm, and supraclavicular region of a 19-year-old man. He had been burned by high-voltage electricity and exhibited a right auricular defect. We innovatively created a prefabricated expanded island flap constructed with an anastomosed vascular pedicle buried in the anterior thoracic chest, followed by flap transfer, tissue re-expansion, and sculpted autologous costal cartilage implantation. The remnant ear was successfully reconstructed in a three-stage surgical procedure.Conclusions: All the flaps survived well without any complications. The reconstructed right ear had a natural shape and a clear structure without apparent displacement and deformation during follow-up. The patient was satisfied with the final appearance, and his neck mobility markedly improved. Advantages and disadvantages were discussed. This procedure explored a novel solution to construct an auricular framework covering for patients who do not have high-quality donor skin and lack anastomotic vessels in the recipient area.

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“…Tissue expanders are balloons that are inserted subcutaneously and gradually inflated. 72 Over time, surplus skin will develop over the ballooned area, which then can be used as a defect-closing flap. For expansion, an area with undamaged skin next to the area to be covered is preferable.…”

Section: Burn Wound Coveragementioning

confidence: 99%

An Introduction to Burn Care: The Sequel

Hermans

2024

Adv Skin Wound Care

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Care of burns, particularly those that are deep and/or extensive, requires a very specific approach from a multidisciplinary team of different types of experts. In contrast to many chronic lesions, large burns are also immediately life-threatening and have significant systemic effects that require specialized treatment as well. This article provides a high-level overview of burn care with an emphasis on these burn-specific issues and treatment. GENERAL PURPOSE To review burn care, with an emphasis on burn-specific issues and treatment. TARGET AUDIENCE This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES After participating in this educational activity, the participant will: 1. Select the appropriate treatment guidelines for patients who have burn injuries. 2. Identify common complications of major burns. 3. Choose the recommended pharmacologic approaches to burn care.

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Tissue expanders; review of indications, results and outcome during 15 years’ experience

Cited by 15 publications

References 96 publications

Transcriptome Profiling Reveals Important Transcription Factors and Biological Processes in Skin Regeneration Mediated by Mechanical Stretch

Transcriptome Profiling Reveals Important Transcription Factors and Biological Processes in Skin Regeneration Mediated by Mechanical Stretch

Creating a re-expanded prefabricated island flap constructed with an anastomosed vascular pedicle for burned ear reconstruction: a case report

An Introduction to Burn Care: The Sequel

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