Tissue Engineering Strategies Applied in Bone Regeneration and Bone Repair

Delpierre, Alexis; Savard, Guillaume; Renaud, M.; Rochefort, Gaël Y.

doi:10.3390/bioengineering10060644

Cited by 4 publications

(1 citation statement)

References 17 publications

(20 reference statements)

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“…As a result, it is crucial to investigate novel potential therapeutic strategies that may improve the quality of life of patients, avoiding side effects, including pain, donor site morbidity, rejection, transmission of diseases, and high cost [9]. In this context, the tissue engineering (TE) approach could represent the most promising alternative for bone repair by overcoming these limitations and addressing clinical needs [10]. Bone tissue engineering (BTE) is an innovative and promising alternative to treat bone defects based on the development of biomaterials that support tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

Bone Tissue Engineering and Nanotechnology: A Promising Combination for Bone Regeneration

Bauso,

La Fauci,

Longo

et al. 2024

Biology

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Large bone defects are the leading contributor to disability worldwide, affecting approximately 1.71 billion people. Conventional bone graft treatments show several disadvantages that negatively impact their therapeutic outcomes and limit their clinical practice. Therefore, much effort has been made to devise new and more effective approaches. In this context, bone tissue engineering (BTE), involving the use of biomaterials which are able to mimic the natural architecture of bone, has emerged as a key strategy for the regeneration of large defects. However, although different types of biomaterials for bone regeneration have been developed and investigated, to date, none of them has been able to completely fulfill the requirements of an ideal implantable material. In this context, in recent years, the field of nanotechnology and the application of nanomaterials to regenerative medicine have gained significant attention from researchers. Nanotechnology has revolutionized the BTE field due to the possibility of generating nanoengineered particles that are able to overcome the current limitations in regenerative strategies, including reduced cell proliferation and differentiation, the inadequate mechanical strength of biomaterials, and poor production of extrinsic factors which are necessary for efficient osteogenesis. In this review, we report on the latest in vitro and in vivo studies on the impact of nanotechnology in the field of BTE, focusing on the effects of nanoparticles on the properties of cells and the use of biomaterials for bone regeneration.

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Section: Introductionmentioning

confidence: 99%