Tissue engineering by self-assembly

Peck, Marissa; Dusserre, Nathalie; McAllister, Todd; L’Heureux, Nicolas

doi:10.1016/s1369-7021(11)70117-1

Cited by 84 publications

(53 citation statements)

References 49 publications

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“…Tissue engineering by self-assembly or cell-sheet tissue engineering has been extensively studied over the years for various clinical targets [435][436][437][438][439]. The rationale of this approach is based on the fact that cells can create their own tissue-specific ECM, bypassing the need for artificial devices and their shortfalls.…”

Section: Tissue Engineering By Self-assembly Therapiesmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

179

188

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Section: Tissue Engineering By Self-assembly Therapiesmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

179

188

View full text Add to dashboard Cite

“…However, scaffold-based approaches are often associated with immunogenicity and inflammation responses. Advancements in cell biology, polymer chemistry and engineering, along with better understanding of developmental and morphogenesis processes, have led to the development of bottom-up approaches that utilise the inherent proficiency of cells to create highly sophisticated tissue-like structures, termed tissue engineering by self-assembly / scaffold-free tissue engineering / cell sheet tissue engineering / modular tissue engineering (1)(2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Accelerated Development of Supramolecular Corneal Stromal-Like Assemblies from Corneal Fibroblasts in the Presence of Macromolecular Crowders

Kumar

Satyam

Fan

et al. 2015

Tissue Engineering Part C: Methods

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Tissue engineering by self-assembly uses the cells' secretome as a regeneration template and biological factory of trophic factors. Despite the several advantages that have been witnessed in preclinical and clinical settings, the major obstacle for wide acceptance of this technology remains the tardy extracellular matrix formation. In this study, we assessed the influence of macromolecular crowding (MMC)/excluding volume effect, a biophysical phenomenon that accelerates thermodynamic activities and biological processes by several orders of magnitude, in human corneal fibroblast (HCF) culture. Our data indicate that the addition of negatively charged galactose derivative (carrageenan) in HCF culture, even at 0.5% serum, increases by 12-fold tissue-specific matrix deposition, while maintaining physiological cell morphology and protein/gene expression. Gene analysis indicates that a glucose derivative (dextran sulfate) may drive corneal fibroblasts toward a myofibroblast lineage. Collectively, these results indicate that MMC may be suitable not only for clinical translation and commercialization of tissue engineering by self-assembly therapies, but also for the development of in vitro pathophysiology models.

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“…Peck et al observed that prolonged culture of cells in the presence of ascorbate led to the massive deposition of collagen in both human umbilical smooth muscle cells and skin fibroblasts [112]. The cell-derived collagen sheets were initially formed and then rolled over a mandrel to form a tubular structure.…”

Section: Scaffolds For Tebvmentioning

confidence: 99%