Tissue distribution of marbofloxacin in pigs after a single intramuscular injection

Yang, Fan; Liu, Yiming; Li, Zhili; Liu, Baobao; Zhao, Zhensheng; Zhou, Baoyuan; Wang, Guoyong

doi:10.4142/jvs.2017.18.2.169

Cited by 9 publications

(22 citation statements)

References 20 publications

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“…The results obtained in the present study confirmed that the absorption and distribution of marbofloxacin administered to rabbits via intramuscular injection reach high levels in a short time in kidney, liver, lung and muscle which were in agreement with the previous reports [10, 16,17,19]. Marbofloxacin remained within the detectable limit till the 5 th day in most tested tissues, while in kidney it remained till the 7 th day following last administration of the drug.…”

Section: Discussionsupporting

confidence: 82%

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Determination of Marbofloxacin residues in Rabbit Tissues by HPLC

Aziz

El‐Nabtity

Barawy³

et al. 2017

Zagazig Veterinary Journal

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The present study was designed to evaluate marbofloxacin residues in different rabbit tissues after multiple intramuscular administrations. For that purpose, rabbits were divided into two groups; the first group (n=21) administered 2mg/kg marbofloxacin for five successive days, while the second group (n=3) were untreated and served as controls. th and 21 st day after the last dose post administration of the drug. Liver, kidneys, pectoral muscle and thigh muscles, spleen, heart, blood and lung from each rabbit were taken, extracted and marbofloxacin residues were analyzed using high-performance liquid chromatographic method with ultraviolet detection. Results indicated a widespread distribution of marbofloxacin in the most tested tissues. It remained within detectable level till the 5 th day in liver and serum while it continues till the 7 th in kidneys day following the last dose. Therefore, muscles of rabbits treated with marbofloxacin could be consumed safely following the 1 st day post treatment, while liver and kidneys could be consumed safely in the 3 rd day after treatment without any hazards on consumers as the residual level below the recommended MRL (150µg/kg).

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Section: Discussionsupporting

confidence: 82%

“…This finding is in agreement with Ding et al [10] and Anadon et al [16] who reported that marbofloxacin concentration in kidney was more than that in liver. But is contrast with Ligabue et al [17] and Yang et al [19] who reported that marbofloxacin concentration in liver was more than that in kidney.…”

Section: Discussioncontrasting

confidence: 51%

Determination of Marbofloxacin residues in Rabbit Tissues by HPLC

Aziz

El‐Nabtity

Barawy³

et al. 2017

Zagazig Veterinary Journal

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“…MBF is distributed widely throughout the animals’ bodies, which could reach 1.6 times higher drug concentrations in the skin than in the plasma in dogs, and MBF concentrations in the plasma can remain above the MIC (>24 h) longer than the dose density ( Cester et al, 1996 ; Schneider et al, 1996 ). Although some studies have reported the pharmacokinetics of MBF in animals including pigs ( Ding et al, 2010 ; Schneider et al, 2014 ; Yang et al, 2016 ), the pharmacokinetic data of MBF in pigs plasma and intestinal content are not sufficient enough to precisely predict the efficacy of this drug.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin and PK/PD Modeling against Escherichia coli in Pigs

et al. 2017

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The aim of this study was to evaluate the activity of marbofloxacin and establish the optimal dose regimens for decreasing the development of fluoroquinolone resistance in pigs against Escherichia coli with ex vivo pharmacokinetic/pharmacodynamic (PK/PD) modeling. The recommended dose (2 mg/kg body weight) of marbofloxacin was orally administered in healthy pigs. The ileum content and plasma were both collected for the determination of marbofloxacin. The main parameters of Cmax, AUC0-24 h, AUC, Ke, t1/2ke, MRT and Clb were 11.28 μg/g, 46.15, 77.81 μg⋅h/g, 0.001 h-1, 69.97 h, 52.45 h, 0.026 kg/h in ileum content, and 0.55 μg/ml, 8.15, 14.67 μg⋅h/ml, 0.023 h-1, 30.67 h, 34.83 h, 0.14 L/h in plasma, respectively In total, 218 E. coli strains were isolated from most cities of China. The antibacterial activity in vitro and ex vivo of marbofloxacin against E. coli was determined following CLSI guidance. The MIC90 of sensitive strains (142) was calculated as 2 μg/ml. The minimum inhibitory concentration (MIC) of HB197 was 2 and 4 μg/ml in broth and ileum fluids, respectively. In vitro mutant prevention concentration, growth and killing-time in vitro and ex vivo of marbofloxacin against selected HB197 were assayed for pharmacodynamic studies. According to the inhibitory sigmoid Emax modeling, the value of AUC0-24 h/MIC produced in ileum content was achieved, and bacteriostatic, bactericidal activity, and elimination were calculated as 16.26, 23.54, and 27.18 h, respectively. Based on Monte Carlo simulations to obtain 90% target attainment rate, the optimal doses to achieve bacteriostatic, bactericidal, and elimination effects were 0.85, 1.22, and 1.41 mg/kg.bw for 50% target, respectively, and 0.92, 1.33, and 1.53 mg/kg.bw for 90% target, respectively, after oral administration. The results in this study provided a more optimized alternative for clinical use and demonstrated that the dosage 2 mg/kg of marbofloxacin by oral administration could have an effect on bactericidal activity against E. coli.

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“…literature (Ding et al, 2010;Schneider et al, 2014;Yang et al, 2017). As shown in Table 1, Cmax increased in a dose dependent manner.…”

Section: Resultsmentioning

confidence: 77%

“…Marbofloxacin is a synthetic third-generation fluoroquinolone with a broad spectrum of activity, licensed only for animals. It is particularly indicated to treat respiratory infections, metritis-mastitis-agalactia syndrome, and to treat skin and soft tissue infections in animals (Yang et al, 2017). Fluoroquinolones are concentration dependent antimicrobial agents.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic / Pharmacodynamic Evaluation of Marbofloxacin for Common Pathogens in Swine Following Single Intramuscular Administration of Different Doses

Rambaldi¹,

Barbarossa²,

Morbidelli³

et al. 2018

PVJ

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The aims of the present work were to study the pharmacokinetics of marbofloxacin 10% solution after single i.m. administration at doses of 6, 8, 10 mg/kg b.w. in swine of 20 weeks of age, to estimate the PK/PD indices using bibliographic MIC90 values and to assess the tolerability of the drug. Marbofloxacin Cmax increased in a dose dependent manner, however animals receiving the 10 mg/kg b.w. dose revealed slightly lower AUCi compared to those receiving 8 mg/kg b.w. This suggests a potential alteration of the elimination mechanisms, evidenced by Cltot values after administration of the three dosages. According to the results of the study, the three tested dosages are well tolerated and active for 2-3 days against the most common pathogens in swine. In particular, 8 mg/kg appeared to be the most suitable dose, since 6 mg/kg might be insufficient against the less susceptible pathogens and 10 mg/kg seemed not to provide any advantage.To Cite This Article: Rambaldi J, Barbarossa A, Morbidelli E and Zaghini A, 2018. Pharmacokinetic/ pharmacodynamic evaluation of marbofloxacin for common pathogens in swine following single intramuscular administration of different doses. Pak Vet J, 38(2): 222-224. http://dx.

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Tissue distribution of marbofloxacin in pigs after a single intramuscular injection

Cited by 9 publications

References 20 publications

Determination of Marbofloxacin residues in Rabbit Tissues by HPLC

Determination of Marbofloxacin residues in Rabbit Tissues by HPLC

Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin and PK/PD Modeling against Escherichia coli in Pigs

Pharmacokinetic / Pharmacodynamic Evaluation of Marbofloxacin for Common Pathogens in Swine Following Single Intramuscular Administration of Different Doses

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