Tissue disposition and depletion of penicillin G after oral administration with milk in unweaned dairy calves

Musser, Jeffrey M.B.; Anderson, Kevin L.; Boison, Joe O.

doi:10.2460/javma.2001.219.346

Cited by 6 publications

(11 citation statements)

References 19 publications

(10 reference statements)

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“…The penicillin concentration in the plasma at this same time is approximately 5 ng/mL. A similar 10:1 ratio has been reported in dairy calves by Musser et al. (2001).…”

Section: Resultssupporting

confidence: 87%

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Bovine kidney tissue/biological fluid correlation for penicillin

Chiesa

Bredow

Smith

et al. 2006

Vet Pharm & Therapeutics

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Penicillin is one of the most commonly misused drugs in steers and dairy cows. In the US, at slaughter the tolerance is 50 ng/g in kidney and other edible tissues. If the tolerance is exceeded, the carcass may not be used for human food. A preslaughter test for penicillin in an easily accessible biological fluid is needed to predict if the concentration of penicillin is below tolerance in the kidney before the bovine is slaughtered. In this study, 12 steers were injected three times with the approved dose (7000 IU) of penicillin at 12-h intervals. Blood and urine samples were collected at intervals after the final dose of penicillin. At each sampling point, one kidney biopsy sample was collected by laparoscopic surgery in the live animal. Another kidney sample was collected at slaughter. Correlations between plasma and kidney concentrations and between urine and kidney concentrations were determined. These correlations predict with 95% confidence that 99% of the animals will have kidney tissue below penicillin tolerance when the plasma concentration of penicillin is below 0.4 ng/mL and/or the urine penicillin concentration is below 140 ng/mL.

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“…The penicillin concentration in the plasma at this same time is approximately 5 ng/mL. A similar 10:1 ratio has been reported in dairy calves by Musser et al. (2001).…”

Section: Resultssupporting

confidence: 87%

“…The penicillin concentration in the plasma at this same time is approximately 5 ng/ mL. A similar 10:1 ratio has been reported in dairy calves by Musser et al (2001). This observation suggests that a concentration of less than 5 ng/mL in the plasma should correlate with a lower than tolerance concentration in the kidney.…”

Section: Analysis Resultssupporting

confidence: 87%

Bovine kidney tissue/biological fluid correlation for penicillin

Chiesa

Bredow

Smith

et al. 2006

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

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“…35 That practice has been associated with violative tissue drug residues in calves, 39 and FARAD has estimated slaughter WDIs for veal calves fed colostrum from cows treated with antimicrobials during the dry period (ie, the approx 45-to 60-day period prior to calving during which a dairy cow is not milked). 40 Results of other studies 41,42 likewise indicate that feeding calves milk replacer containing penicillin G or amoxicillin can result in violative tissue residues of those drugs. In 1988, calves fed milk or colostrum from medicated cows accounted for 39 of the 460 (8.5%) residue violations identified by the FDA.…”

Section: Waste Milk and Colostrummentioning

confidence: 99%

Considerations for extralabel drug use in calves

Mzyk¹,

Gehring²,

Tell³

et al. 2017

javma

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“…showed that it has to potential to be a good matrix for ante mortem sampling, but animal hydration status and consistency of status must be taken into account (Schneider et al, 2009). Musser et al (2001) showed that penicillin remains in higher concentrations in the urine for a greater length of time than in either tissues or serum in a study of oral penicillin G administration in dairy calves. That study determined urine would make a good ante mortem sample for residue testing (Musser et al, 2001).…”

Section: Alternative Residue Testing Matricesmentioning

confidence: 99%

“…Musser et al (2001) showed that penicillin remains in higher concentrations in the urine for a greater length of time than in either tissues or serum in a study of oral penicillin G administration in dairy calves. That study determined urine would make a good ante mortem sample for residue testing (Musser et al, 2001).…”

Section: Alternative Residue Testing Matricesmentioning

confidence: 99%

Analysis of procaine penicillin G and ampicillin trihydrate residue depletion profiles in tissues and alternative matrices of cull sows

Mainquist-Whigham¹

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This project determined the tissue, plasma, and urine residue depletion of procaine penicillin G in cull sows at label and extra-label doses, with corresponding calculation of withdrawal times. We also examined the utility of urine, plasma, and environmental samples as matrices for residue analysis, the potential for environmental residue contamination, and the performance of rapid tests kits KIS™, Charm MRL™, and Snap™ test in detecting residues. Forty-seven sows were assigned to a treatment group receiving 3,000 IU/lb IM SID procaine penicillin G (n=15), 15,000 IU/lb IM SID procaine penicillin G (n=16), or a negative control group receiving sterile saline injections (n=16). Sows were sampled at 1, 6, 14, and 28 days post-treatment. With a 25 ppb action level, kidney withdrawal time for extra label dosing at 15,000 IU/lb was determined to be 30 days. Injection site withdrawal time was estimated to be 37 days. Urine and plasma could both serve as representative matrices for ante-mortem residue testing. Snap™ and Charm MRL™ test kits on urine returned similar results to LC-MS/MS testing, making them good ante mortem screening tests. Environmental samples are not a good tool for residue detection and there is no evidence to support the environmental transfer of penicillin G from treated to untreated sows.

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Tissue disposition and depletion of penicillin G after oral administration with milk in unweaned dairy calves

Cited by 6 publications

References 19 publications

Bovine kidney tissue/biological fluid correlation for penicillin

Bovine kidney tissue/biological fluid correlation for penicillin

Considerations for extralabel drug use in calves

Analysis of procaine penicillin G and ampicillin trihydrate residue depletion profiles in tissues and alternative matrices of cull sows

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