Tissue Blood Flow in the Digestive Organs of Rats With Acute Pancreatitis After Corvitin Administration

Vovkun, T.V.; Yanchuk, Petro I.; Shtanova, L. Ya.; Shalamay, A. S.

doi:10.15407/fz61.06.053

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…In Ukraine, corvitin is used in clinical cardiology as a blocker of 5lipoxy genase activity in the treatment of coronary heart disease and myocardial infarction [12]. In our pre vious stu dies, we found that this drug increased tis suebloodflowinthegastricmucosaandliver [13].In other studies, we observed the accelerated recovery oftissuebloodflowinthepancreas,gastricmucosa and liver of rats with acute pancreatitis following the treatment with corvitin [14]. In addition, recently, we have found that corvitin increased biliary content of both free and conjugated with amino acids BAs in rats depending on the tested doses [15].…”

supporting

confidence: 61%

Corvitin modulates the content of lipids in rat liver bile

Vovkun¹,

Yanchuk²,

Shtanova³

et al. 2019

Ukr.Biochem.J

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Quercetin (QUE) and its water-soluble form сorvitin are medicinally important members of the flavonoid family and the most prominent dietary antioxidants. Numerous pharmacological effects of quercetin include protection against diseases, such as atherosclerosis, myocardial infarction, and cerebrovascular disea ses. Corvitin modulates liver blood flow but its effects on liver lipid metabolism have not been understood. We investigated the influence of corvitin (2.5, 5, 10 mg/kg) on the formation and secretion of cholesterol (Chol), cholesterol esters (EChol), phospholipids (PLs), free fatty acids (FFAs), and triglycerides (TGs) into the bile. Secreted bile was collected during 2.5 h of the experiment. Lipid fractions of the bile were separated by thin-layer chromatography. We defined that administration of corvitin caused a significant (P < 0.05-0.001) increase in levels of all studied lipid components of bile. At a dose of 2.5 and 5 mg/kg corvitin increased bile content of Chol, PLs and FFAs,and at a dose of 10 mg/kg had the largest effect on the total production of EChol and TGs. We concluded that corvitin activates the liver lipids metabolism and processes of bile formation.

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supporting

confidence: 61%

Corvitin modulates the content of lipids in rat liver bile

Vovkun¹,

Yanchuk²,

Shtanova³

et al. 2019

Ukr.Biochem.J

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“…This statement is supported by observations that reduction in pancreatic blood flow increases the severity of acute pancreatitis [ 78 ], whereas improvement of pancreatic blood flow reduces the severity of acute pancreatitis and accelerates pancreatic recovery in this disease [ 79 , 80 ]. Previous studies have shown that the flavonoid quercetin [ 81 , 82 ] increased pancreatic blood flow in AP which translated into tissue protective effects and accelerated pancreatic recovery. Such observations suggest that the protective effect of tricetin on the pancreas in cerulein-induced AP may be, at least in part, related to the improvement of pancreatic blood flow.…”

Section: Discussionmentioning

confidence: 99%

Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress-Induced DNA Damage Signaling

et al. 2022

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Acute pancreatitis (AP) poses a worldwide challenge due to the growing incidence and its potentially life-threatening course and complications. Specific targeted therapies are not available, prompting the identification of new pathways and novel therapeutic approaches. Flavonoids comprise several groups of biologically active compounds with wide-ranging effects. The flavone compound, tricetin (TCT), has not yet been investigated in detail but sporadic reports indicate diverse biological activities. In the current study, we evaluated the potential protective effects of TCT in AP. TCT (30 μM) protected isolated primary murine acinar cells from the cytotoxic effects of cerulein, a cholecystokinin analog peptide. The protective effects of TCT were observed in a general viability assay (calcein ester hydrolysis), in an apoptosis assay (caspase activity), and in necrosis assays (propidium iodide uptake and lactate dehydrogenase release). The effects of TCT were not related to its potential antioxidant effects, as TCT did not protect against H2O2-induced acinar cell death despite possessing radical scavenging activity. Cerulein-induced expression of IL1β, IL6, and matrix metalloproteinase 2 and activation of nuclear factor-κB (NFκB) were reduced by 30 μM TCT. In vivo experiments confirmed the protective effect of TCT in a mouse model of cerulein-induced AP. TCT suppressed edema formation and apoptosis in the pancreas and reduced lipase and amylase levels in the serum. Moreover, TCT inhibited interleukin-1β (IL1β), interleukin-6 (IL6), and tumor necrosis factor-α (TNFα) expression in the pancreas and reduced the activation of the oxidative DNA damage sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1). Our data indicate that TCT can be a potential treatment option for AP.

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“…In our previous studies, using corvitin, a water-soluble analogue of quercetin, we have shown a significant increase in tissue blood flow in the rat gastric mucosa and the liver (Vinogradova et al 2012;Vovkun et al 2014). In another study, we observed accelerated recovery of tissue blood flow in the pancreas, gastric mucosa and the liver of rats with acute pancreatitis following the treatment with corvitin (Vovkun et al 2015). In addition, recently we have found that corvitin increases biliary content of both free and conjugated with amino acids BAs in rats depending on the tested doses (Vovkun et al 2016).…”

Section: Introductionmentioning

confidence: 86%

Water-soluble quercetin modulates the choleresis and bile lipid ratio in rats

Vovkun

Yanchuk²,

Shtanova³

et al. 2018

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Water-soluble analogue of quercetin, corvitin is used in patients with myocardial infarction as blocker of 5-lipoxygenase. However, its effects on secretion, lipid content and physico-chemical properties of bile have not been understood yet. We investigated the effect of corvitin, applied in different doses, on the level of bile ﬂow, the content of bile free and esterified cholesterol, phospholipids, triacylglycerols, and free fatty acids. In order to determine stability of the bile colloidal system, we examined the relationship between different lipid components. The rats were injected intraportally with a bolus of corvitin. At doses of 2.5, 5, and 10 mg/kg, the latter increased bile flow and concentration of total cholates, as well as free fatty acids. Corvitin (5 mg/kg) elevated phospholipids and cholesterol content, but at a dose of 10 mg/kg it increased the concentration of bile cholesterol esters and triacylglycerols. Corvitin applied at doses of 2.5 and 10 mg/kg increased total cholates/cholesterol ratio, but at a dose of 10 mg/kg, the drug reduced cholesterol / esterified cholesterol ratio. The results suggest that corvitin exerts choleretic effect and improves stability of bile colloidal system.

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Tissue Blood Flow in the Digestive Organs of Rats With Acute Pancreatitis After Corvitin Administration

Cited by 6 publications

References 18 publications

Corvitin modulates the content of lipids in rat liver bile

Corvitin modulates the content of lipids in rat liver bile

Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress-Induced DNA Damage Signaling

Water-soluble quercetin modulates the choleresis and bile lipid ratio in rats

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