Tissue and blood T-lymphocyte subpopulations in erythema nodosum leprosum

Immunohistochemical studies of leprous neuritis

“…These findings are in accordance with what Modlin et al (14) found in skin lesions of leprosy. The shift in the ThiTs ratio in nerve lesions throughout the spectrum of the disease corresponded with the observations re ported by Modlin et al (23,24) and Narayanan et al (15,16) in skin lesions. The staining pattern of the T cell subpopulations with a peripheral segregation in the infiltrates of Ts cells in contrast to the more dispersed Th cells was more evident in the skin lesions than the nerv es.…”

Analysis of naturally occurring delayed-type hypersensitivity reactions in leprosy by in situ hybridization.

“…In contrast, ENL reactions may be visualized as a transient diminution of Ts activity, leading to partial augmentation of Th activity. We have reported a transient diminution of Ts activity in vitro during ENL episodes (24) . The diminution of Ts regulation could account for the augmentation of both cell-mediated immunity and antibody formation characteristic of ENL reactions.…”

In situlocalization of T lymphocyte subsets in human paracoccidioidomycosis

“…Conversely, helper T cells were the predominant population in the lesions. The prevalence of helper T cells at sites of disease introduces the concept of lymphocyte recirculation and stresses the point that the lesional infiltrate may not always reflect the peripheral blood cell subsets [7].…”