TiPpIng the balance in histone acetylation

Roach, Lara; Mostoslavsky, Raúl

doi:10.1038/s42255-021-00396-6

Nat Metab

2021

DOI: 10.1038/s42255-021-00396-6

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TiPpIng the balance in histone acetylation

Lara Roach

Raúl Mostoslavsky

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2023

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Dynamic metabolism during early mammalian embryogenesis

Zhao,

Wang,

Zhang

et al. 2023

Development

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Dynamic metabolism is exhibited by early mammalian embryos to support changing cell fates during development. It is widely acknowledged that metabolic pathways not only satisfy cellular energetic demands, but also play pivotal roles in the process of cell signalling, gene regulation, cell proliferation and differentiation. Recently, various new technological advances have been made in metabolomics and computational analysis, deepening our understanding of the crucial role of dynamic metabolism during early mammalian embryogenesis. In this Review, we summarize recent studies on oocyte and embryo metabolism and its regulation, with a particular focus on its association with key developmental events such as fertilization, zygote genome activation and cell fate determination. In addition, we discuss the mechanisms of certain metabolites that, in addition to serving as energy sources, contribute to epigenetic modifications.

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Dynamic metabolism during early mammalian embryogenesis

Zhao,

Wang,

Zhang

et al. 2023

Development

View full text Add to dashboard Cite

show abstract

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TiPpIng the balance in histone acetylation

Cited by 1 publication

References 10 publications

Dynamic metabolism during early mammalian embryogenesis

Dynamic metabolism during early mammalian embryogenesis

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