1985
DOI: 10.1111/j.1751-1097.1985.tb08940.x
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Abstract: Tin(1V)-protoporphyrin chloride, a proposed chemotherapeutic agent for prevention of neonatal hyperbilirubinemia, is a potent photosensitizer of bilirubin destruction in vitro at visible wavelengths (410, 540, 580 nm). We speculate that the drug may have phototoxic effects in vivo if it accumulates in light-accessible tissues.

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Cited by 37 publications
(20 citation statements)
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“…We cannot exclude an effect of SnPP to stimulate these pathways and accelerate the reduction of serum bilirubin. SnPP could be acting as a photosensitizer to enhance bilirubin destruction (27). This appears unlikely because the present experiments, including the assay for bilirubin, were performed under dim light.…”
Section: Resultsmentioning
confidence: 98%
“…We cannot exclude an effect of SnPP to stimulate these pathways and accelerate the reduction of serum bilirubin. SnPP could be acting as a photosensitizer to enhance bilirubin destruction (27). This appears unlikely because the present experiments, including the assay for bilirubin, were performed under dim light.…”
Section: Resultsmentioning
confidence: 98%
“…Although many Mps have been shown to effectively inhibit bilirubin production, their clinical use has been viewed critically. Mps can affect nitric oxide synthase or soluble guanylyl cyclase (10,11), can increase gene expression and protein levels of the inducible HO-1 (12), and are potential photosensitizers (13)(14)(15). Tin protoporphyrin (SnPP) and tin mesoporphyrin (SnMP) have been studied in human neonates regarding their safety and efficacy (16,17), however, both showed photosensitizing effects in animal models (18), which led to the abandonment of SnPP.…”
mentioning
confidence: 99%
“…Although this does not demonstrate a cause-and-effect relationship between phototoxicity-mediated mortality and lipid peroxidation, it suggests an association between the two. Previous in vitro studies demonstrated that SnPP can be activated by photons, leading to an excited state of the porphyrin structure (3,4,16). This molecule can then be quenched by molecular oxygen yielding singlet oxygen, a toxic molecule known to cause cell damage, and a relaxed porphyrin.…”
Section: Content Of CD Increased In Liver Tissue Of Animals Treatedmentioning
confidence: 99%