2012
DOI: 10.1055/s-0032-1322627 View full text |Buy / Rent full text
|
|

Abstract: Delayed heparin administration after cardiac death does not affect thrombus formation in an animal model of lung procurement after cardiac death. Concern about clinically significant thrombosis occurring when heparin is not given before cardiac arrest appears unfounded. These findings suggest that DCD lungs can be used regardless of antemortem heparin administration.

Help me understand this report

Search citation statements

Order By: Relevance
Select...
1
1
1
1
0
7
0

Year Published

2013
2013
2020
2020

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

0
7
0
Order By: Relevance
“…Contrary to this report, Keshava et al demonstrated that DCD lungs could be used regardless of ante-mortem heparin administration (62). To date there is no clinical study to compare pre-mortem heparin use versus no heparin use.…”
Section: Donor Selection Criteria Cdcd Donorsmentioning
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1.2b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 14 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 130,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Contrary to this report, Keshava et al demonstrated that DCD lungs could be used regardless of ante-mortem heparin administration (62). To date there is no clinical study to compare pre-mortem heparin use versus no heparin use.…”
Section: Donor Selection Criteria Cdcd Donorsmentioning
“…This supports our recent experimental findings of delayed heparin administration in a pig DCD model, in which it appears that heparin can be administered at least 25 minutes after cardiac standstill without the formation of gross or microvascular thrombi in the lungs. 3 Potential explanations of this lack of thrombosis after DCD arrest are as follows: (1) passive circulation after cardiac arrest continues for several minutes as a result of an intrinsic gradient between the systemic arterial and central venous pressures, 4 (2) the period between cardiac arrest and organ procurement is brief, and (3) antegrade and retrograde flushing with heparinized pulmoplegia effectively eliminates any residual blood. 5 We conclude that nonheparinized Maastricht Category III DCD human lungs do not appear to harbor thrombi when harvested using antegrade and retrograde flush enriched with heparin.…”
Section: Discussionmentioning
“…In a DCD pig model Sanchez et al showed that premortem heparin administration did improve EVLP evaluation by possibly maintaining endothelial homeostasis [55]. In another pig experiment, Keshava et al [56] showed no difference in thrombus formation after flushing of the recovered lungs. To date, no comparative clinical study was performed and centers with or without heparin administration have reported equally good outcome [20].…”
Section: Donation After Circulatory Death Lung Criteria and Protocolsmentioning