Time-restricted feeding reduces high-fat diet associated placental inflammation and limits adverse effects on fetal organ development

Upadhyay, Aditya; Anjum, B; Godbole, Nachiket M.; Rajak, Sangam; Shukla, Pooja; Tiwari, Swasti; Sinha, Rohit Anthony; Godbole, Madan M.

doi:10.1016/j.bbrc.2019.04.154

Cited by 20 publications

(16 citation statements)

References 41 publications

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“…In the present study, the sensitivity of inflammation to MO was opposite to that of autophagy at different developmental stages. Previous studies showed opposite trend of autophagy and inflammation in kidney (Nguyen et al, 2017;Sato et al, 2019), adipose tissue (Jansen et al, 2012), and placenta (Upadhyay et al, 2019) of offspring in response to maternal malnutrition. Considering the complex crosstalk between autophagy and inflammation (Harris et al, 2017;Deretic and Klionsky, 2018;Matsuzawa-Ishimoto et al, 2018), the possible mechanisms could be that 1) the inflammatory cytokines may inhibit the autophagy in early gestation stage, but were depressed by other factors in later gestation stage and after birth; or 2) the autophagy raised in the later stage inhibited the expression of inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 82%

Maternal Overnutrition During Gestation in Sheep Alters Autophagy Associated Pathways in Offspring Heart

et al. 2022

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Poor maternal nutrition during gestation can negatively affect offspring growth, development, and health pre- and post-natally. Overfeeding during gestation or maternal obesity (MO) results in altered metabolism and imbalanced endocrine hormones in animals and humans which will have long-lasting and detrimental effects on offspring growth and health. In this study, we examined the effects of overnutrition during gestation on autophagy associated pathways in offspring heart muscles at two gestational and one early postnatal time point (n = 5 for treated and untreated male and female heart respectively at each time point). Two-way ANOVA was used to analyze the interaction between treatment and sex at each time point. Our results revealed significant interactions of maternal diet by developmental stages for offspring autophagy signaling. Overfeeding did not affect the autophagy signaling at mid-gestation day 90 (GD90) in both male and female offspring while the inflammatory cytokines were increased in GD90 MO male offsrping; however, overfeeding during gestation significantly increased autophagy signaling, but not inflammation level at a later developmental stage (GD135 and day 1 after birth) in both males and females. We also identified a sexual dimorphic response in which female progeny were more profoundly influenced by maternal diet than male progeny regardless of developmental stages. We also determined the cortisol concentrations in male and female hearts at three developmental stages. We did not observe cortisol changes between males and females or between overfeeding and control groups. Our exploratory studies imply that MO alters autophagy associated pathways in both male and female at later developmental stages with more profound effects in female. This finding need be confirmed with larger sample numbers in the future. Our results suggest that targeting on autophagy pathway could be a strategy for correction of adverse effects in offspring of over-fed ewes.

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Section: Discussionmentioning

confidence: 82%

Maternal Overnutrition During Gestation in Sheep Alters Autophagy Associated Pathways in Offspring Heart

et al. 2022

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“…In future work, direct assessment of the placenta in these groups is necessary to understand the contribution of placental pathology on offspring programming. This is especially important as the placenta may be a major source of inflammatory response with lipid transfer and also a major source for establishing the type of inflammatory response in offspring 53–55 .…”

Section: Discussionmentioning

confidence: 99%

Programming effects of maternal and gestational obesity on offspring metabolism and metabolic inflammation

Chang

Hafner

Varghese

et al. 2019

Sci Rep

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With the increasing prevalence of obesity in women of reproductive age there is a need to understand the ramifications of this on offspring. The purpose of this study is to investigate the programming effects of maternal obesity during preconception and the preconception/gestational period on adiposity and adipose tissue inflammation in offspring using an animal model. Adult female C57Bl/6J mice were assigned either normal diet, high fat diet (HFD) prior to pregnancy, or HFD prior to and through pregnancy. Some offspring were maintained on normal diet while others started HFD later in life. Offspring were assessed for body composition and metabolic responses. Lipid storing tissues were evaluated for expansion and inflammation. Male offspring from the preconception group had the greatest weight gain, most subcutaneous adipose tissue, and largest liver mass when introduced to postnatal HFD. Male offspring of the preconception/gestation group had worsened glucose tolerance and an increase in resident (CD11c−) adipose tissue macrophages (ATMs) when exposed to postnatal HFD. Female offspring had no significant difference in any parameter between the diet treatment groups. In conclusion, this study demonstrates that prenatal and pregnancy windows have independent programming effects on offspring. Preconception exposure affects body composition and adiposity while gestation exposure affects metabolism and tissue immune cell phenotypes.

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“…Furthermore, TRF regimen mice show reduction in severity of hyperinsulinemia, hepatic steatosis and inflammation, despite the consumption of similar quantities of high-fat diet (HFD) as compared to the ad libitum group (43). Interestingly, TRF also mitigates the effect of maternal HFD feeding on fetal hepatic steatosis (44). However, results from clinical trials to test the efficacy of TRF in human NAFLD/NASH are still awaited.…”

Section: Time Restricted Feedingmentioning

confidence: 99%

Current treatment paradigms and emerging therapies for NAFLD/NASH

et al. 2021

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Time-restricted feeding reduces high-fat diet associated placental inflammation and limits adverse effects on fetal organ development

Cited by 20 publications

References 41 publications

Maternal Overnutrition During Gestation in Sheep Alters Autophagy Associated Pathways in Offspring Heart

Maternal Overnutrition During Gestation in Sheep Alters Autophagy Associated Pathways in Offspring Heart

Programming effects of maternal and gestational obesity on offspring metabolism and metabolic inflammation

Current treatment paradigms and emerging therapies for NAFLD/NASH

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