Time of Origin of Neurons in the Brain Stem of the Mouse

Pierce, Elizabeth Taber

doi:10.1016/s0079-6123(08)60679-2

Cited by 182 publications

(54 citation statements)

References 16 publications

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“…This expansive spatial origin (r3-r7) together with its prolonged birth dating (E11-E16; Pierce, 1973) is in contrast to the more spatially and temporally confined origins of many of the other migrations.…”

Section: Ventral and Pontine Migrationsmentioning

confidence: 89%

“…An extensive literature describes the rhombic lip origins and migrations of the hindbrain neural crest (e.g., Nichols, 1981Nichols, , 1987Tan and Morris-Kay, 1985;Trainor et al, 2002). The rhombic lip and the hindbrain cell populations that migrate from it have been examined using classic morphological stains (see Essick, 1912), experimental manipulation (Harkmark, 1954;Tan and LeDouarin, 1991), autoradiography (Miale and Sidman, 1961;Pierce, 1966Pierce, , 1967Pierce, , 1973Pierce, , 1975Altman and Bayer, 1987a-d), dye lineage tracing (Wingate and Hatten, 1999), viral cell lineage tracing (Lin et al, 2001), and conditional gene expression lineage tracing (Rodriguez and Dymecki, 2000;Fü nfschilling and Reichardt, 2002). In addition, some insights into the genetic regulation of the lip have been gathered Wingate, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Migratory routes and fates of cells transcribing the Wnt‐1 gene in the murine hindbrain

Nichols

Bruce

2005

Developmental Dynamics

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Section: Ventral and Pontine Migrationsmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Migratory routes and fates of cells transcribing the Wnt‐1 gene in the murine hindbrain

Nichols

Bruce

2005

Developmental Dynamics

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“…4 A, white arrow). Although their location appears to coincide with the posterior precerebellar extramural stream, which has been suggested to be the path for MF neurons in LRN and ECN (Wang et al, 2005), those neurons are produced at later stages (approximately E12.5) and from a more dorsal region, the Math1 domain (Pierce, 1973;Landsberg et al, 2005;Wang et al, 2005). Furthermore, it was shown in Figure 2 that those MF neurons in LRN and ECN are not in the Ptf1a lineage.…”

Section: Dynamic Movement Of Cf Neurons Produced From the Ptf1a Domainmentioning

confidence: 90%

“…Kawauchi et al, 2006) and that they are produced at approximately E10.5-E11.5 (Pierce, 1973). Several transcriptional factors, such as Lmx1a (LIM homeobox transcription factor 1␣), Math1, and Ngn1, are expressed in this region (Akazawa et al, 1995;Ben-Arie et al, 1996;Landsberg et al, 2005).…”

Section: Mf Neurons Are Not In the Ptf1a Lineagementioning

confidence: 99%

Origin of Climbing Fiber Neurons and Their Developmental Dependence onPtf1a

Yamada¹,

Terao²,

Terashima³

et al. 2007

J. Neurosci.

106

122

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Climbing fiber (CF) neurons in the inferior olivary nucleus (ION) extend their axons to Purkinje cells, playing a crucial role in regulating cerebellar function. However, little is known about their precise place of birth and developmental molecular machinery. Here, we describe the origin of the CF neuron lineage and the involvement of Ptf1a ( pancreatic transcription factor 1a) in CF neuron development. Ptf1a protein was found to be expressed in a discrete dorsolateral region of the embryonic caudal hindbrain neuroepithelium. Because expression of Ptf1a is not overlapping other transcription factors such as Math1 (mouse atonal homolog 1) and Neurogenin1, which are suggested to define domains within caudal hindbrain neuroepithelium (Landsberg et al., 2005), we named the neuroepithelial region the Ptf1a domain. Analysis of mice that express ␤-galactosidase from the Ptf1a locus revealed that CF neurons are derived from the Ptf1a domain. In contrast, retrograde labeling of precerebellar neurons indicated that mossy fiber neurons are not derived from Ptf1a-expressing progenitors. We could observe a detailed migratory path of CF neurons from the Ptf1a domain to the ION during embryogenesis. In Ptf1a null mutants, putative immature CF neurons produced from this domain were unable to migrate or differentiate appropriately, resulting in a failure of ION formation. Apoptotic cells were observed in the mutant hindbrain. Furthermore, the fate of some cells in the Ptf1a lineage were changed to mossy fiber neurons in Ptf1a null mutants. These findings clarify the precise origin of CF neurons and suggest that Ptf1a controls their fate, survival, differentiation, and migration during development.

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“…We used Islet1 as a general motor neuron marker (Ericson et al, 1992). In wild-type embryos, trigeminal branchiomotor neurons arose from the ventral region of r2 and r3 between E9.5 and E10.5 (Taber Pierce, 1973;Marshall et al, 1992) and migrated dorsolaterally to form the trigeminal motor nucleus (Fig. 2 A, arrowhead, Q) (Altman and Bayer, 1982), which extended in the dorsolateral position of r2 and r3.…”

Section: Mash1(؊/؊);math3(؊/؊) Mutantsmentioning

confidence: 99%

Mash1andMath3Are Required for Development of Branchiomotor Neurons and Maintenance of Neural Progenitors

Ohsawa¹,

Ohtsuka²,

Kageyama³

2005

J. Neurosci.

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Basic helix-loop-helix (bHLH) transcription factors are known to play important roles in neuronal determination and differentiation. However, their exact roles in neural development still remain to be determined because of the functional redundancy. Here, we examined the roles of neural bHLH genes Mash1 and Math3 in the development of trigeminal and facial branchiomotor neurons, which derive from rhombomeres 2-4. In Math3-null mutant mice, facial branchiomotor neurons are misspecified, and both trigeminal and facial branchiomotor neurons adopt abnormal migratory pathways. In Mash1;Math3 double-mutant mice, trigeminal and facial branchiomotor neurons are severely reduced in number partly because of increased apoptosis. In addition, neurons with migratory defects are intermingled over the midline from either side of the neural tube. Furthermore, oligodendrocyte progenitors of rhombomere 4 are reduced in number. In the absence of Mash1 and Math3, expression of Notch signaling components is severely downregulated in rhombomere 4 and neural progenitors are not properly maintained, which may lead to intermingling of neurons and a decrease in oligodendrocyte progenitors. These results indicate that Mash1 and Math3 not only promote branchiomotor neuron development but also regulate the subsequent oligodendrocyte development and the cytoarchitecture by maintaining neural progenitors through Notch signaling.

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Time of Origin of Neurons in the Brain Stem of the Mouse

Cited by 182 publications

References 16 publications

Migratory routes and fates of cells transcribing the Wnt‐1 gene in the murine hindbrain

Migratory routes and fates of cells transcribing the Wnt‐1 gene in the murine hindbrain

Origin of Climbing Fiber Neurons and Their Developmental Dependence onPtf1a

Mash1andMath3Are Required for Development of Branchiomotor Neurons and Maintenance of Neural Progenitors

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