Aims The present study aims to evaluate the relationship between time management and professional self-efficacy with the quality of nursing care in nurses of northwest Iran.Background Nowadays time is a vital factor in medical interventions. Time management and self-efficacy are crucial for retrieving the best nursing care standards.Methods This correlational study was conducted in Ardabil, northwest of Iran, in 2023. In these 350 nurses have been categorized by stratified sampling method. For data collection, we used Raj’a Nayef Zyoud's(2023) time management inventory, Masoumeh Bakhtiari et al(2023) professional self-efficacy of nurses inventory, and Anita Karaca et al(2022) nursing care quality inventory. The collected data were analyzed in SPSS software (26) using descriptive statistics, independent t-test, analysis of variance, Pearson correlation coefficients, and linear regression stepwise model.Result The results revealed that Time management (80.3%), Professional Self-efficacy (61.7%), and Quality of nursing care (57.1%) were at a moderate level. Also, the mean value of the time management score, professional self-efficacy score, and nursing care quality score were (59.79 ± 10.37), (72.64 ± 12.34), and (45.151 ± 16.78), respectively. There was a meaningful relationship between time management and professional self-efficacy with the quality of nursing care (p < 0.001). The stepwise multiple linear regression model showed that time management (65%) was a stronger predictor than professional self-efficacy (62%) on the quality of nursing care.Conclusion contributing nurses in this study had shown a medium level of nursing care. We suggest that medical politicians conduct workshops to upgrade time management skills and the professional self-efficacy of nurses so that the quality of nursing care improves as well.