2008
DOI: 10.1097/wnr.0b013e3282f2adfd
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Abstract: The time-dependent effect of transcranial direct current stimulation (tDCS) on working memory was investigated by applying anodal stimulation over the left prefrontal cortex. This single-blind, sham-controlled crossover study recruited 15 healthy participants. A three-back verbal working-memory task was performed before, during, and 30 min after 1 mA anodal or sham tDCS. Anodal tDCS, compared with sham stimulation, significantly improved working-memory performance. Accuracy of response was significantly increa… Show more

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Cited by 338 publications
(262 citation statements)
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“…They showed different interventions, which differed in the number of sessions and study design, thus making difficult compare them. Other variables, such as intensity of current, stimulated area, stimulation time and methods used to measure the outcomes were similar, corroborating with protocols used by other authors in different populations that investigated the same outcomes (19,20) . It is known that after stroke may occur a change in synaptic homeostasis, which affects individuals' cognition (21) .…”
Section: Discussionsupporting
confidence: 84%
“…They showed different interventions, which differed in the number of sessions and study design, thus making difficult compare them. Other variables, such as intensity of current, stimulated area, stimulation time and methods used to measure the outcomes were similar, corroborating with protocols used by other authors in different populations that investigated the same outcomes (19,20) . It is known that after stroke may occur a change in synaptic homeostasis, which affects individuals' cognition (21) .…”
Section: Discussionsupporting
confidence: 84%
“…In these studies researchers have applied anodal tDCS to the left prefrontal cortex with the consistent finding that stimulation improved verbal WM performance using 2-and 3-back WM tasks (Fregni et al, 2005a;Ohn et al, 2008;Andrews et al, 2011;Mulquiney et al, 2011;Zaehle et al, 2011). These results also showed that cathodal stimulation of the left prefrontal cortex did not improve accuracy on the task.…”
Section: Introductionmentioning
confidence: 91%
“…In a related working memory task, the beneficial effects of anodal tDCS on performance accuracy developed during stimulation, and were stable for up to 30 min after the completion of stimulation [30] . Zaehle and co-workers [31] described similar positive effects of left prefrontal anodal tDCS on response accuracy in an n-back working memory task, while cathodal tDCS disturbed performance.…”
Section: Working Memorymentioning
confidence: 97%