2016
DOI: 10.1016/j.physbeh.2016.02.007
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Abstract: High-fat diet (HFD) induced obesity is associated not only with metabolic dysregulation, e.g., impaired glucose homeostasis and insulin sensitivity, but also with neurological dysfunction manifested with aberrant behavior and/or neurotransmitter imbalance. Most studies have examined HFD's effects predominantly in male subjects, either in the periphery or on the brain, in isolation and after a finite feeding period. In this study, we evaluated the time-course of selected metabolic, behavioral, and neurochemical… Show more

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Cited by 56 publications
(31 citation statements)
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“…With this paradigm we did not see robust weight gain in female mice. This is consistent with studies in which female C57B/6 mice did not out-gain their low fat fed counterparts until 6 to 9 weeks on HFD (Krishna, et al, 2016; Lee, et al, 2010; Yang, et al, 2014). In previous experiments with fixed doses of nicotine, female rats tended to be more sensitive to nicotine’s effects of on body weight and food intake than males and were especially vulnerable to increased food intake and weight gain during nicotine withdrawal (Bowen, et al, 1986; Grunberg, Popp, & Winders, 1988).…”
Section: Discussionsupporting
confidence: 91%
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“…With this paradigm we did not see robust weight gain in female mice. This is consistent with studies in which female C57B/6 mice did not out-gain their low fat fed counterparts until 6 to 9 weeks on HFD (Krishna, et al, 2016; Lee, et al, 2010; Yang, et al, 2014). In previous experiments with fixed doses of nicotine, female rats tended to be more sensitive to nicotine’s effects of on body weight and food intake than males and were especially vulnerable to increased food intake and weight gain during nicotine withdrawal (Bowen, et al, 1986; Grunberg, Popp, & Winders, 1988).…”
Section: Discussionsupporting
confidence: 91%
“…NIC did not reduce body weight gain in animals on either diet. The lack of effect of HFD compared to CHOW in this group may be due to a delayed response to HFD diet in female mice, since in previous studies substantial weight gain in female C57BL/6 mice did not occur until more than 6 weeks on HFD (Krishna et al, 2016; Lee et al, 2010; Sparks and Pauly, 1999; Yang et al, 2014). Net weight change from the start of nicotine access reflected a similar relationship, with no differences across groups.…”
Section: Resultsmentioning
confidence: 67%
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“…In our studies, we did not self-select rats based on diet consumption. Furthermore, it has been suggested that the length and exposure history of a calorie-rich food can have fundamentally different behavioral outcomes (Krishna et al, 2016; Tracy et al, 2015). For example, short-term access to a palatable food has been shown to induce anxiolytic behavior and increase in food motivation, whereas increase in anxiety-like behavior and decrease in food motivation has been reported following chronic HFD exposure in rodents (Davis et al, 2008; la Fleur et al, 2007; Sharma et al, 2012; Ulrich-Lai et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
“…Utilizing this limited access (2hr) paradigm, we have recently shown that binge-like intake of high fat diet (HFD) induced anxiolytic effects and attenuated alcohol consumption in non-dependent rats (Sirohi et al, 2016). This finding could be explained by the length and exposure history of a calorie-rich food, which has fundamentally different behavioral outcomes (Krishna et al, 2016; Tracy et al, 2015) or changes in the feeding peptides, which control behavioral constructs such as motivation and anxiety that also contribute to excess alcohol intake (Barson and Leibowitz, 2016; Morganstern et al, 2011). Therefore, in the present study, we hypothesized that extended intermittent access to HFD would lead to increased alcohol consumption in non-dependent rodents.…”
Section: Introductionmentioning
confidence: 99%