Tick-borne tularemia. An outbreak of lymphadenopathy in children

Markowitz, L E; Hynes, Noreen A.; Cruz, Peter De; Campos, Elisabete Ferreira Esteves; Barbaree, James M.; Plikaytis, Brian D.; Mosier, Donald E.; Kaufmann, Arnold F.

doi:10.1001/jama.254.20.2922

Cited by 51 publications

(32 citation statements)

References 12 publications

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“…The MIC results indicated that these nine b-lactams would be ineffective for the treatment of tularemia patients, while the MIC distribution suggested that some Japanese isolates were susceptible to cephalosporins, cephamycin, carbapenems, and monobactam (Table 2). Our results and those of previous reports (11,14,16) suggest that cephalosporin-susceptible F. tularensis isolates are distributed in Japan and North America. Cephalosporins are frequently used to clinically treat patients with suspected bacterial infections (17).…”

supporting

confidence: 89%

In Vitro Antibiotic Susceptibility of <i>Francisella tularensis</i> Isolates from Japan

et al. 2013

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SUMMARY:The antibiotic susceptibilities of 36 isolates of Japanese Francisella tularensis, an etiological agent of the zoonotic disease tularemia, were analyzed using the E test. All the isolates were susceptible to ciprofloxacin, doxycycline, erythromycin, and gentamicin but resistant to benzylpenicillin and cephalothin. The susceptibility to seven other b-lactams (aztreonam, cefotaxime, cefoxitin, ceftriaxone, cefuroxime, imipenem, and meropenem) varied among the isolates. These findings suggest that the guidelines for the antibiotic treatment of tularemia issued by the World Health Organization are appropriate for Japanese tularemia patients.

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confidence: 89%

In Vitro Antibiotic Susceptibility of <i>Francisella tularensis</i> Isolates from Japan

et al. 2013

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“…Further work is needed to determine whether our fi ndings will apply to other deer fl y-associated outbreaks or for outbreaks of tularemia associated with ticks, which are known to maintain as well as transmit F. tularensis. Notably, while investigating a tick-borne outbreak of presumed type B infections in South Dakota, Markowitz and colleagues found evidence of both type A and type B strains in Dermacentor variabilis ticks collected from dogs (14). Outbreaks involving multiple serotypes have been observed with other vector-borne pathogens, including dengue virus (15), which suggests that amplifi cation and transmission of multiple strains in a focal area may represent a general feature of some vector-borne diseases.…”

Section: Discussionmentioning

confidence: 99%

MultipleFrancisella tularensisSubspecies and Clades, Tularemia Outbreak, Utah

Petersen¹,

Carlson²,

Dietrich³

et al. 2008

Emerg. Infect. Dis.

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In July 2007, a deer fl y-associated outbreak of tularemia occurred in Utah. Human infections were caused by 2 clades (A1 and A2) of Francisella tularensis subsp. tularensis. Lagomorph carcasses from the area yielded evidence of infection with A1 and A2, as well as F. tularensis subsp. holarctica. These fi ndings indicate that multiple subspecies and clades can cause disease in a localized outbreak of tularemia.

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“…Only a few in vitro studies have determined the antibiotic susceptibilities of F. tularensis isolates (13,111). All strains tested have been susceptible to most antibiotics, including aminoglycosides.…”

Section: Selected Examples Of Clinical Activity Of Aminoglycosidesmentioning

confidence: 99%