volume 7, issue 4, P241-255 2015
DOI: 10.18632/aging.100739
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Andrew Do, Vinal Menon, Xu Zhi, Adam Gesing, Denise S. Wiesenborn, Adam Spong, Liou Sun, Andrzej Bartke, Michal M. Masternak

Abstract: Ames dwarf (df/df) mice lack growth hormone (GH), thyroid stimulating hormone and prolactin. Treatment of juvenile df/df mice with GH alone stimulates somatic growth, reduces insulin sensitivity and shortens lifespan. Early‐life treatment with thyroxine (T4) alone produces modest growth stimulation but does not affect longevity. In this study, we examined the effects of treatment of juvenile Ames dwarf mice with a combination of GH + T4 and compared them to the effects of GH alone. Treatment of female and male…

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