2015
DOI: 10.18632/aging.100739
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Abstract: Ames dwarf (df/df) mice lack growth hormone (GH), thyroid stimulating hormone and prolactin. Treatment of juvenile df/df mice with GH alone stimulates somatic growth, reduces insulin sensitivity and shortens lifespan. Early‐life treatment with thyroxine (T4) alone produces modest growth stimulation but does not affect longevity. In this study, we examined the effects of treatment of juvenile Ames dwarf mice with a combination of GH + T4 and compared them to the effects of GH alone. Treatment of female and male… Show more

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Cited by 12 publications
(12 citation statements)
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References 56 publications
(12 reference statements)
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“…When DR is applied to the GHRKO, no additional insulin sensitivity is observed, nor is there an extension of lifespan in contrast to the Ames dwarf. However, when GH is combined with thyroxine treatment for 6 wk in juvenile Ames mice, no effect on longevity is observed (31). Treatment with growth hormone in vitro and in vivo decreases antioxidative enzyme activities and glutathione and methionine metabolism in Ames mice (21,59).…”
Section: Physiological Characteristics Of Long-living Micementioning
confidence: 96%
See 1 more Smart Citation
“…When DR is applied to the GHRKO, no additional insulin sensitivity is observed, nor is there an extension of lifespan in contrast to the Ames dwarf. However, when GH is combined with thyroxine treatment for 6 wk in juvenile Ames mice, no effect on longevity is observed (31). Treatment with growth hormone in vitro and in vivo decreases antioxidative enzyme activities and glutathione and methionine metabolism in Ames mice (21,59).…”
Section: Physiological Characteristics Of Long-living Micementioning
confidence: 96%
“…However, lifelong treatment of Snell dwarf mice with thyroxine shortened lifespan such that treated mice lived 83% of the untreated-dwarf lifespan (110). A more recent report indicated that Ames mice treated with GH and thyroxine between the ages of 2 and 8 wk did not reduce lifespan to match wild-type controls yet increased body weights of the dwarf mice to that of untreated wild-type mice (ϳ18 g) (31). Mutations that impact GH status, both spontaneous and engineered, strongly support a major role for GH in lifespan regulation.…”
Section: Interventions That Alter Gh or Igf-i)mentioning
confidence: 99%
“…(ii) Bartke and colleagues, have dealt intensively into various conditions of GH deficit and ageing (198,242) and recently reported that a short (6 weeks) phase of early exposure to GH (starting at 2 weeks age) reduced lifespan and cellular stress resistance in Ames dwarf mice (243). A parallel thyroxine treatment had no effect on lifespan (243,244,245) whereas thyroxine and GH combined treatment reduced maximal lifespan in only female Ames mice (246). (iii) Extensive work by Brown-Borg and colleagues have described epigenetic signatures in DNA methylation patterns in Ames mice compared to their WT littermates (247,248).…”
Section: Future Directions Of Lifespan Studies On Ghrko Micementioning
confidence: 99%
“…Unexpectedly, concomitant treatment of juvenile Ames dwarf mice with thyroxine severely reduced (in females) or eliminated (in males) the effect of early GH treatment on longevity [42]. Treatment with thyroxine alone during the same period (between 2 and 8 weeks or age) had no significant impact on longevity [42] and 11 weeks of treatment of Snell dwarfs starting at 4 weeks of age similarly failed to affect their longevity [24].…”
Section: Is Aging Related To Gh Actions At Particular Stages Of Thmentioning
confidence: 99%
“…Treatment with thyroxine alone during the same period (between 2 and 8 weeks or age) had no significant impact on longevity [42] and 11 weeks of treatment of Snell dwarfs starting at 4 weeks of age similarly failed to affect their longevity [24]. These findings were counterintuitive.…”
Section: Is Aging Related To Gh Actions At Particular Stages Of Thmentioning
confidence: 99%