Thyrotropin versus thyroid hormone in regulating bone density and turnover in premenopausal women

Baqi, L; Payer, Juraj; Killinger, Zdenko; Hruzikova, P.; Čierný, Daniel; Susienkova, K; Langer, P

doi:10.4149/endo_2010_02_57

Cited by 18 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…positive correlation with the femoral hip and lumbar spine BMD [ 10 ] . Women older than 65, who had a low serum TSH level, were at increased risk for vertebral and hip fractures [ 11 ] .…”

mentioning

confidence: 89%

“…For example, Mazzioti showed in postmenopausal women that a low-normal TSH value correlated with a higher prevalence of vertebral fractures [ 21 ] . In addition Baqi compared postmenopausal women with low and normal TSH level and found that irrespectively of the T4 level women with normal TSH level had a higher BMD of the lumbar spine and the femur [ 10 ] . It has been shown that both hyperthyroidism and hypothyroidism are risk factors for the hip fracture in older men [ 22 ] .…”

mentioning

confidence: 99%

See 1 more Smart Citation

TSH Prevents Bone Resorption and with Calcitriol Synergistically Stimulates Bone Formation in Rats with Low Levels of Calciotropic Hormones

et al. 2014

View full text Add to dashboard Cite

Thyroid-stimulating hormone exerts both antiresorptive and anabolic effects on bone remodeling in aged ovariectomized rats and thyroid stimulating hormone-receptor null mice, supported by clinical results demonstrating that low thyroid-stimulating hormone level is associated with increased bone loss. To further explore the effect of thyroid-stimulating hormone on bone metabolism we introduced here a rat model with removed thyroid and parathyroid glands to obtain low serum concentrations of thyroid and parathyroid hormone, calcitonin and 1,25(OH)2D3. Surgery resulted in hypocalcemia, low parathyroid and thyroid hormone, 1,25(OH)2D3, C-telopeptide, and osteocalcin serum level. Intermittent administration of thyroid-stimulating hormone resulted in a further decrease of serum calcium and decreased level of serum C-telopeptide due to the suppression of bone resorption, while in the same animals osteocalcin in serum was higher indicating an increased bone formation rate. A combination of thyroid-stimulating hormone and 1,25(OH)2D3 significantly increased the serum Ca2+, C-telopeptide and serum osteocalcin values. MicroCT analyses of the distal femur and proximal tibia showed that rats treated with 1,25(OH)2D3 alone or in a combination with thyroid-stimulating hormone had an increased trabecular bone volume, and enhanced trabecular bone quality. Biomechanical testing of the trabecular bone showed an increased maximal load for 105% and 235%, respectively, in rats treated with 1,25(OH)2D3 alone, or in a combination with thyroid-stimulating hormone. We suggest that thyroid-stimulating hormone independently of calciotropic hormones suppressed bone resorption and stimulated bone formation, while in combination with 1,25(OH)2D3 acted synergistically on bone formation resulting in an increased bone volume.

show abstract

“…positive correlation with the femoral hip and lumbar spine BMD [ 10 ] . Women older than 65, who had a low serum TSH level, were at increased risk for vertebral and hip fractures [ 11 ] .…”

mentioning

confidence: 89%

mentioning

confidence: 99%

TSH Prevents Bone Resorption and with Calcitriol Synergistically Stimulates Bone Formation in Rats with Low Levels of Calciotropic Hormones

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The previous data of suppressive doses of levothyroxine therapy on bone mass and bone turnover in premenopausal women are limited. However, some studies on hypothyroid premenopausal women with long-term levothyroxine therapy showed increased bone turnover and increased resorptive changes, but not osteoporosis [33][34][35]. Hyperthyroid patients also have serum BTMs concentrations significantly higher in comparison with euthyroid subjects, in relation to thyroid hormones excess and high bone turnover [36] .…”

Section: Original Papermentioning

confidence: 99%

Effects of levothyroxine therapy on bone mineral density and bone turnover markers in premenopausal women with thyroid cancer after thyroidectomy

Duan

Liu

et al. 2020

Endokrynologia Polska

View full text Add to dashboard Cite

Introduction:We investigated the impact of long-term levothyroxine (LT4) treatment on bone mineral density (BMD) and bone turnover markers (BTMs) in premenopausal women with differentiated thyroid cancer (DTC) after thyroidectomy. Material and methods: Sixty-five premenopausal women who received LT4 therapy at least one year (range, 1.5-9.0 years) after thyroidectomy for DTC and 50 premenopausal women without thyroid diseases were enrolled in this study. We measured the Z-scores of lumbar and hip BMD, serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), intact parathyroid hormone (iPTH), N-terminal propeptide of type 1 N procollagen (P1NP), C-terminal telopeptide of type 1 collagen (CTX-1), calcium (Ca), phosphorus (P), vitamin D3, and alkaline phosphatase (ALP) in all participants. Results: In DTC subjects, serum TSH levels were lower, and serum FT4, P1NP, CTX-1, and ALP levels were higher compared with controls. The prevalence of low BMD was higher in DTC subjects than in controls. Multivariate logistic regression analysis showed that serum TSH levels were negatively associated with CTX-1 and ALP. Conclusions: We found a high prevalence of low BMD among premenopausal women who received long-term LT4 therapy for DTC after thyroidectomy. Long-term TSH suppression therapy was a significant risk factor for decreased bone strength, mainly by increasing bone turnover. (Endokrynol Pol 2020; 71 (1): 15-20)Effects of LT4 treatment on BMD and BTMs in premenopausal women with DTC after thyroidectomy Duan Bin-Hong et al.the consent form were enrolled in the study. All study protocols were carried out in accordance with the declaration of Helsinki [24]. Statistical analysisStatistical analysis was performed using IBM SPSS version 20.0 (IBM Corp., Armonk, NY, USA). Categorical data were evaluated in terms of frequency and percentage, and continuous data were presented as means ± standard deviation. Chi-square test was used to compare the prevalence of osteoporosis and osteopaenia between two groups. The variables were compared using twosample t-test. Pearson correlation analysis was used to estimate the relationship of thyroid hormones with Z-scores of BMD and BTMs. The odds ratios (ORs) and 95% confidence intervals (CIs) for FT3, FT4, and TSH, in association with Z-scores of BMD, iPTH, P1NP, CTX-1, Ca, P, vitamin D3, and ALP were analysed using multivariate logistic regression. The p-value < 0.05 was considered as statistically significant.

show abstract

“… 172 - 174 TSH levels vary inversely with serum osteocalcin levels. 175 - 177 Serum osteocalcin is directly correlated with tumor growth in both hormone independent and hormone-dependent tumors. 178 , 179 The wide-ranging impact of osteocalcin on the structure (bones) and function (metabolism) of the body cannot be overstated, thus its key role in the biology of functions, where it is involved in over 60% of the indexes.…”

Section: The Biomarkersmentioning

confidence: 99%

Endobiogeny: A Global Approach to Systems Biology (Part 2 of 2)

Lapraz¹,

Hedayat²,

Pauly³

2013

Glob Adv Health Med

View full text Add to dashboard Cite

Endobiogeny and the biology of functions are based on four scientific concepts that are known and generally accepted: (1) human physiology is complex and multifactorial and exhibits the properties of a system; (2) the endocrine system manages metabolism, which is the basis of the continuity of life; (3) the metabolic activity managed by the endocrine system results in the output of biomarkers that reflect the functional achievement of specific aspects of metabolism; and (4) when biomarkers are related to each other in ratios, it contextualizes one type of function relative to another to which is it linked anatomically, sequentially, chronologically, biochemically, etc.

show abstract

Thyrotropin versus thyroid hormone in regulating bone density and turnover in premenopausal women

Cited by 18 publications

References 0 publications

TSH Prevents Bone Resorption and with Calcitriol Synergistically Stimulates Bone Formation in Rats with Low Levels of Calciotropic Hormones

TSH Prevents Bone Resorption and with Calcitriol Synergistically Stimulates Bone Formation in Rats with Low Levels of Calciotropic Hormones

Effects of levothyroxine therapy on bone mineral density and bone turnover markers in premenopausal women with thyroid cancer after thyroidectomy

Endobiogeny: A Global Approach to Systems Biology (Part 2 of 2)

Contact Info

Product

Resources

About