Thyrotropin Levels Are Associated with Cardiometabolic Risk Factors in Euthyroid Adolescents

Abstract

Background: Increased thyrotropin (TSH) levels and free triiodothyronine to free thyroxine (fT3:fT4) ratios, even within the euthyroid range, have been associated with cardiometabolic risk factors in adults but are less characterized in youth. This study sought to determine relations between TSH, thyroid hormones, and cardiometabolic risk factors in euthyroid adolescents. Methods: Data were extracted from the United States National Health and Nutrition Examination Survey, 2007-2010, for univariate and multivariate analyses of TSH, thyroid hormones, body mass index (BMI), blood pressure, lipids, and glucose metabolism. Subjects aged 12-18 years, with normal TSH and antithyroid peroxidase antibody levels, and without a history of thyroid disease, diabetes, or treatment of hypertension/dyslipidemia (n = 1167) were included. TSH and thyroid hormones were assessed for impact on BMI Z-score, systolic blood pressure (SBP) diastolic blood pressure, total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, triglycerides, and glucose metabolism. Results: Univariate analyses revealed positive linear relations between TSH and SBP, TC, fasting and two-hour glucose, and homeostasis model assessment of insulin resistance (HOMA-IR). The fT3:fT4 ratio negatively correlated with high-density lipoprotein cholesterol but positively with BMI Z-score, SBP, triglycerides, fasting and two-hour glucose, fasting insulin, and HOMA-IR. In multivariate analyses controlling for age, sex, race/ ethnicity, and BMI Z-score, relations between TSH and both TC and fasting glucose remained significant, and the fT3:fT4 ratio was positively associated with fasting glucose and HOMA-IR. Conclusions:In an unselected population of euthyroid U.S. adolescents, TSH and thyroid hormones correlate with multiple cardiometabolic risk factors, with age-and sex-independent effects on cholesterol and glucose metabolism.

Pro-health education in the fight against obesity and its complications in school-age children – 6-month programme of cooperation with the child and parents

“…The higher the TSH level, the higher the diastolic blood pressure. Similar observations were made by Lee et al, who reported higher systolic blood pressure in adolescents aged 12-19 with elevated TSH levels [11]. The relationship between the thyroid hormone level and the value of the arterial pressure, confirmed in both studies, is of great clinical significance.…”

Thyroid hormone associated with Acanthosis Nigricans and fat distribution in obese patients

“…Thyroid hormone take part in regulating basal metabolism, thermogenesis and also play an important role in glucose-lipid metabolism [12]. Previous study has shown that FT3/FT4 ratio negatively associated with HDL-C and positively with TG in euthyroid adolescents [13]. In this study, we found that FT3 was significantly negatively with HDL-C in all obesity.…”

“…About glucose metabolism, TSH is positively correlated with 2 h-glucose and HOMA-IR in youth with euthyroid [13]. FT3/FT4 ratio was positively with fasting and 2 h-glucose, fasting insulin and HOMA-IR [13].…”

Association of Subclinical Hypothyroidism and Cardiovascular Disease With Mortality

“…37,38 Low thyroid hormone levels also increase systemic vascular resistance and induce endothelial dysfunction by reducing nitric oxide availability. [37][38][39] Previous studies, [5][6][7]40 including those using NHANES data, 5,7 reported that low thyroid function even within the normal range is associated with metabolic syndrome owing to an increase in insulin resistance and might contribute to the progression of atherosclerosis and CVD risk. 41 While the exact underlying mechanisms are still unclear, these biological mechanisms support our finding that CVD partially mediates the association of higher TSH concentrations with death.…”