Thyroid hormones and modulation of diastolic function: a promising target for heart failure with preserved ejection fraction

Neves, João Sérgio; Vale, Catarina; Hafe, Madalena von; Borges‐Canha, Marta; Leite, Ana Rita; Almeida-Coelho, João; Lourenço, André; Falcão-Pires, Inês; Carvalho, Davide; Leite‐Moreira, Adelino

doi:10.1177/2042018820958331

Cited by 18 publications

(17 citation statements)

References 94 publications

(159 reference statements)

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“…Recent clinical studies have reported that patients with cardiovascular disease who have reduced T3 levels have a higher risk of death from heart failure ( Wang et al, 2017 ; Neves et al, 2019 ). Rezvi et al reviewed thyroid hormone supplementation in HF ( Neves et al, 2020 ). Studies in patients without HF as well as HFrEF suggest an effect of thyroid hormone supplementation in improving diastolic function ( Pingitore et al, 2008 ).…”

Section: Hypothyroidism and The Cardiovascular Systemmentioning

confidence: 99%

Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside

et al. 2021

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Thyroid hormones (THs) are synthesized in the thyroid gland, and they circulate in the blood to regulate cells, tissues, and organs in the body. In particular, they exert several effects on the cardiovascular system. It is well known that THs raise the heart rate and cardiac contractility, improve the systolic and diastolic function of the heart, and decrease systemic vascular resistance. In the past 30 years, some researchers have studied the molecular pathways that mediate the role of TH in the cardiovascular system, to better understand its mechanisms of action. Two types of mechanisms, which are genomic and non-genomic pathways, underlie the effects of THs on cardiomyocytes. In this review, we summarize the current knowledge of the action of THs in the cardiac function, the clinical manifestation and parameters of their hemodynamics, and treatment principles for patients with hyperthyroid- or hypothyroid-associated heart disease. We also describe the cardiovascular drugs that induce thyroid dysfunction and explain the mechanism underlying the thyroid toxicity of amiodarone, which is considered the most effective antiarrhythmic agent. Finally, we discuss the recent reports on the involvement of thyroid hormones in the regulation of myocardial regeneration and metabolism in the adult heart.

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Section: Hypothyroidism and The Cardiovascular Systemmentioning

confidence: 99%

Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside

et al. 2021

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“…Thyroid hormones have a direct and indirect cellular effect on the cardiac-renal-vascular system 8 . Excess T3 causes tachycardia, diminished systemic vascular, increased cardiac preload and ventricular contractility 16 , resulting in increased cardiac output and hypertension 8 . The results of a study in Hong Kong stated that 591 patients with hyperthyroidism, 9% were accompanied by hypertension, and the prevalence of heart failure was higher in patients with hypertension 17 .…”

Section: Discussionmentioning

confidence: 99%

Association of Thyroid Function with Metabolic Parameter in IDD Clinic Patients, Magelang Research and Development Center

Nurcahyani,

Kumorowulan,

Sukandar

et al. 2021

MLU

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Metabolic parameters, such as lipid and glucose metabolism, blood pressure, and body weight, are influenced by thyroid hormones. Thyroid dysfunction may lead to the development of the metabolic syndrome. The study aimed to analyze the relationship between thyroid dysfunction and metabolic parameters in IDD clinic patients, Magelang Research and Development Center. A cross-sectional study of 83 patients who met the inclusion and exclusion criteria. Total cholesterol, LDL, HDL, TSH, and free T4 concentration had been measured in all subjects. BMI and blood pressure were measured. Concentrations of lipids, triglycerides, free T4, and TSH were analyzed. The mean age of the patient was 33.5 ± 8.6 of whom 6 (7.2 %) subclinical hypothyroidism, 17 (20.5 %) overt hyperthyroidism, and 17 (20.5 %) had subclinical hyperthyroidism. There was positive relationship between TSH and systolic; whereas, FT4 was associated with BMI, systole, and diastole after adjustment for age. Overt hyperthyroidism had significantly higher odds of hypertension after adjustment for age and BMI ), p<0.05). Hyperthyroidism may induce hypertension.

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Section: Thyroid Hormonesmentioning

confidence: 99%

“…Thyroid hormones impact on cardiovascular system and their alterations increase cardiovascular risk through genomic and non-genomic mechanisms (39)(40). A local cardiac hypothyroidism may be present even if plasmatic thyroid hormones are normal due to an upregulation of type 3 iodothyronine deiodinase (40). Both clinical and subclinical hypothyroidism increase risk of HF (41), and data from epidemiological studies described low triiodothyronine (T3) syndrome in about 22% of HFpEF patients and subclinical hypothyroidism in 10 to 20% (29) (42).…”

Section: Thyroid Hormonesmentioning

confidence: 99%

Anabolic hormones and heart failure with preserved ejection fraction: looking for Ariadne’s thread

Luca¹,

Crisci²,

Giardino³

et al. 2021

Monaldi Arch Chest Dis

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Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome that accounts for more than half of all heart failure patients. Identification, early diagnosis and management of patients are still complex, and no targeted treatment is available, since all tested drugs were not able to lower hard clinical outcomes. A multi-hormonal deficiency syndrome has been described in HFpEF patients suggesting that different hormones may represent new biomarkers of the disease, but their clinical utility is still debated. The natriuretic peptides are the cornerstone biomarker in heart failure, predicting cardiovascular death and heart failure hospitalization. Testosterone and DHEA-S deficiencies have been reported in HFpEF and associated with right ventricular impairment and diastolic dysfunction. IGFBP-1/IGF-1 axis correlates with echocardiographic parameters of HFpEF patients and with several prognostic biomarkers including NT-proBNP and C reactive protein. Low triiodothyronine syndrome is frequently found in HFpEF and thyroid hormones should represent a potential biomarker of risk stratification and prognosis.

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Thyroid hormones and modulation of diastolic function: a promising target for heart failure with preserved ejection fraction

Cited by 18 publications

References 94 publications

Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside

Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside

Association of Thyroid Function with Metabolic Parameter in IDD Clinic Patients, Magelang Research and Development Center

Anabolic hormones and heart failure with preserved ejection fraction: looking for Ariadne’s thread

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