Thyroid hormone modulation of ovarian recrudescence of air-breathing catfish Clarias gariepinus

Supriya, A.; Kavarthapu, Raghuveer; Swapna, I.; Rasheeda, M. K.; Kobayashi, Tohru; Nagahama, Yoshitaka; Gupta, Atul; Majumdar, K. C.; Senthilkumaran, B.

doi:10.1007/s10695-006-0034-1

Cited by 24 publications

(10 citation statements)

References 7 publications

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“…Moreover, the THs may also play critical roles in normal reproduction, sex steroids levels, and expression of steroidogenic enzyme genes [54]. The previous studies have demonstrated that T4 administration in female catfish enhanced the growth rate of ovarian follicles and entry of oocytes into the maturational phase compared with controls in the preparatory phase [55]. In the present study, the increase of maturing oocytes accompanied by an increased in plasma T4 were also observed in the 10 lg/L treatment group.…”

Section: Discussionsupporting

confidence: 74%

Butachlor causes disruption of HPG and HPT axes in adult female rare minnow (Gobiocypris rarus)

Zhu

Zha

et al. 2014

Chemico-Biological Interactions

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a b s t r a c tButachlor is a chloroacetamide herbicide widely used in Asia, and may enter the aquatic environment through agricultural application. In this study, plasma VTG and hormone levels (E2, 11-KT, T3 and T4) were determined after the female rare minnow (Gobiocypris rarus) was exposed to butachlor at environmental relevant concentrations (0, 0.1, 1, and 10 lg/L) for 40 days. The mRNA levels of the HPG axisrelated genes (gnrh, era, vtg, star, lhr, 3b-hsd, cyp11a, cyp17, cyp19a and cyp19b), and the HPT axis-related genes (tra, dio1, dio2, and dio3) were quantified after 20 and 40 days exposure to butachlor. For the HPG axis, the plasma 11-KT was increased at exposure concentration of 10 lg/L, and VTG was significantly decreased at 1 lg/L. Functional genes like gnrh and cyp19b in the brains, star, lhr, cyp11a, 3b-hsd, and cyp19a in the ovaries, and era and vtg in livers were up-regulated. For the HPT axis, the results showed that plasma T4 levels were significantly increased, the gene expression of dio1 was up-regulated, dio2 showed no significant variation, and dio3 was down-regulated in the livers. These results indicated that butachlor may promote the accumulation of T4 in fish through inactive deiodinase type 3. The transcription of HPG axis-related genes could serve as an auto-regulation of hormone levels after exposure to butachlor. Furthermore, the activation of gnrh may play an important role as a feed-back mechanism in the regulation of hormone levels and crosstalk of endocrine axes.

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Section: Discussionsupporting

confidence: 74%

Butachlor causes disruption of HPG and HPT axes in adult female rare minnow (Gobiocypris rarus)

Zhu

Zha

et al. 2014

Chemico-Biological Interactions

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“…(3) Exposure to cortisol results in an increase of the androgen-related machinery and subsequent masculinization in fish (25–27, 84), and mammals (32). (4) Exposition of thyroid hormones could inhibit the aromatase (P450arom/ cyp19a1 ) activity or expression in fish (36, 85), amphibians (46, 47), and mammals (58, 59, 75). TRH, thyrotropin-releasing hormone; Dio1, deiodinase type 1; Dio2, deiodinase type 2; T4, thyroxine; ACTH, pituitary adrenocorticotropic hormone; T (testosterone) 11β-HSD2, type 2 isozyme of 11β-hydroxysteroid dehydrogenase; 11-KT, 11-ketotestosterone; 5α-DHT, 5α-dihydrotestosterone.…”

Section: Hypothalamic Regulation Of Thsmentioning

confidence: 99%

Crossover of the Hypothalamic Pituitaryâ€“Adrenal/Interrenal, â€“Thyroid, and â€“Gonadal Axes in Testicular Development

2014

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Besides the well-known function of thyroid hormones (THs) for regulating metabolism, it has recently been discovered that THs are also involved in testicular development in mammalian and non-mammalian species. THs, in combination with follicle stimulating hormone, lead to androgen synthesis in Danio rerio, which results in the onset of spermatogenesis in the testis, potentially relating the hypothalamic–pituitary–thyroid (HPT) gland to the hypothalamic–pituitary–gonadal (HPG) axes. Furthermore, studies in non-mammalian species have suggested that by stimulating the thyroid-stimulating hormone (TSH), THs can be induced by corticotropin-releasing hormone. This suggests that the hypothalamic–pituitary–adrenal/interrenal gland (HPA) axis might influence the HPT axis. Additionally, it was shown that hormones pertaining to both HPT and HPA could also influence the HPG endocrine axis. For example, high levels of androgens were observed in the testis in Odonthestes bonariensis during a period of stress-induced sex-determination, which suggests that stress hormones influence the gonadal fate toward masculinization. Thus, this review highlights the hormonal interactions observed between the HPT, HPA, and HPG axes using a comparative approach in order to better understand how these endocrine systems could interact with each other to influence the development of testes.

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“…Thyroid hormone receptors are present on teleost ovarian and testicular cells (Nelson and Habibi 2009) and goitrogens affect gonadal development in fishes including increased numbers of Sertoli and germ cells in tilapia ( Oreochromis niloticus ) exposed to thiouracil (PTU) (Matta et al, 2002) and impaired testicular and ovarian recrudescence in catfish ( Clarias gariepinus ) exposed to thiourea (Supriya et al, 2005; Swapna et al, 2006). Perchlorate causes a female bias in the sex ratio of zebrafish (Mukhi et al, 2007a; Sharma and Patiño, 2013), while evidence of masculinization was found in stickleback (Bernhardt et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Developmental timing of sodium perchlorate exposure alters angiogenesis, thyroid follicle proliferation and sexual maturation in stickleback

Furin¹,

Hippel²,

Postlethwait³

et al. 2015

General and Comparative Endocrinology

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Perchlorate, a common aquatic contaminant, is well known to disrupt homeostasis of the hypothalamus-pituitary-thyroid axis. This study utilizes the threespine stickleback (Gasterosteus aculeatus) fish to determine if perchlorate exposure during certain windows of development has morphological effects on thyroid and gonads. Fish were moved from untreated water to perchlorate-contaminated water (30 and 100 mg/L) starting at 0, 3, 7, 14, 21, 42, 154 and 305 days post fertilization until approximately one year old. A reciprocal treatment (fish in contaminated water switched to untreated water) was conducted on the same schedule. Perchlorate exposure increased angiogenesis and follicle proliferation in thyroid tissue, delayed gonadal maturity, and skewed sex ratios towards males; effects depended on concentration and timing of exposure. This study demonstrates that perchlorate exposure beginning during the first 42 days of development has profound effects on stickleback reproductive and thyroid tissues, and by implication can impact population dynamics. Long-term exposure studies that assess contaminant effects at various stages of development provide novel information to characterize risk to aquatic organisms, to facilitate management of resources, and to determine sensitive developmental windows for further study of underlying mechanisms.

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Thyroid hormone modulation of ovarian recrudescence of air-breathing catfish Clarias gariepinus

Cited by 24 publications

References 7 publications

Butachlor causes disruption of HPG and HPT axes in adult female rare minnow (Gobiocypris rarus)

Butachlor causes disruption of HPG and HPT axes in adult female rare minnow (Gobiocypris rarus)

Crossover of the Hypothalamic Pituitaryâ€“Adrenal/Interrenal, â€“Thyroid, and â€“Gonadal Axes in Testicular Development

Developmental timing of sodium perchlorate exposure alters angiogenesis, thyroid follicle proliferation and sexual maturation in stickleback

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