Thyroid dysfunction in COVID-19

Lui, David Tak Wai; Lee, Chi Ho; Woo, Yu Cho; Hung, Ivan Fan Ngai; Lam, Karen Siu Ling

doi:10.1038/s41574-023-00946-w

Cited by 7 publications

(1 citation statement)

References 118 publications

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“…The intricate relationship between SARS-CoV-2 infection and thyroid function is an interesting area of research, with evidence suggesting that thyroid abnormalities, including alterations in hormone levels and structural changes within the gland, are not uncommon sequelae of COVID-19. Previous findings have illuminated the prevalence of reduced free triiodothyronine (FT3) levels in these patients, potentially mirroring systemic inflammation and serving as a harbinger of clinical deterioration [1][2][3][4]. Moreover, the occurrence of non-thyroidal illness (NTI) syndrome or euthyroid sick syndrome (ESS) appears more frequently in severe cases of COVID-19, with a marked reduction in FT3 levels [1].…”

Section: Introductionmentioning

confidence: 99%

Thyroid Density in CT Imaging as a Potential Marker of Lung Involvement in COVID-19: A Retrospective Analysis

Balasubramaniam,

Suresh Kumar,

Pandian

et al. 2024

Cureus

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BackgroundThe SARS-CoV-2 pandemic has underscored the multifaceted impact of the virus on human health, extending beyond the respiratory system to involve other organ systems, including the endocrine system. Emerging evidence suggests a notable interaction between COVID-19 and thyroid function, characterized by alterations in thyroid hormone levels and structural changes within the gland. This study aims to explore the association between thyroid density on CT imaging and lung involvement in patients with COVID-19, potentially offering new insights into the systemic effects of the virus. MethodologyA retrospective cross-sectional analysis was conducted on 1,066 patients with COVID-19 who underwent chest CT scans without contrast at Government Medical College, Omandurar Government Estate, Chennai, which was designated as the COVID-19 care center from April to June 2021. Thyroid density and lung involvement were quantitatively assessed, and their correlation was analyzed using descriptive and inferential statistics, including the Kruskal-Wallis H test and Shapiro-Wilk test for normality. ResultsThe study population predominantly exhibited normal thyroid density (749, 70.3%), followed by altered (212, 19.9%), nodular (104, 9.8%), and a single instance (0.1%) of absent thyroid density. Despite variability in lung involvement across different thyroid density categories, statistical analysis revealed no significant association between thyroid density and the extent of lung involvement in patients with COVID-19. ConclusionsThis study found no significant correlation between thyroid density and lung involvement in patients with COVID-19, suggesting that thyroid density on CT imaging may not serve as a reliable marker for lung involvement in this population. Further research is warranted to explore the complex interactions between COVID-19 and thyroid function, as well as the potential implications for patient management and prognosis.

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Section: Introductionmentioning

confidence: 99%

Thyroid Density in CT Imaging as a Potential Marker of Lung Involvement in COVID-19: A Retrospective Analysis

Balasubramaniam,

Suresh Kumar,

Pandian

et al. 2024

Cureus

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Increased incidence of myxedema coma during the COVID-19 pandemic and in the post pandemic era: a single-center case series

Sokołowski,

Studen,

Opalinska

et al. 2024

Intern Emerg Med

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The COVID-19 pandemic was a major challenge for all health care employees, but it was also difficult for patients to gain access to health care services. Myxedema coma (MC) is an extremely rare but potentially fatal endocrine emergency. The aim of the study was to report an increased incidence of life-threatening myxedema coma that occurred in relation to the COVID-19 pandemic. In this paper, we report a cohort of 11 patients with MC who were treated at the University Hospital in Krakow, Poland, in the period from 2015 to 2023. Only 1 case of MC was recorded in the period from 2015 to 2019, and, in the same area, 10 cases of MC were recorded after the start of COVID-19 pandemic until present. Hypothyroidism was diagnosed de novo in 2 (18%) patients; the remaining patients were severely hypothyroid due to therapy non-compliance. Nine patients had primary hypothyroidism, and 2 had central hypothyroidism. Besides longstanding hypothyroidism, an additional precipitating factor for MC was identified in 4 (36%) of the patients. Due to the inaccessibility of parenteral levothyroxine, patients were treated with oral, mostly liquid, form of levothyroxine. The mortality rate in this cohort was 27.2%. In conclusion, the increase of the incidence of MC, which is a life-threatening complication of inadequately treated hypothyroidism, during the COVID-19 pandemic, when resources were limited, and in the post-pandemic era, underlines the importance of adequate communication with patients and of long-term availability of primary care for patients with thyroid disease.

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