Thyroid Disorders in Children and Adolescents

Hanley, Patrick C; Lord, Katherine; Bauer, Andrew J.

doi:10.1001/jamapediatrics.2016.0486

Cited by 175 publications

(146 citation statements)

References 76 publications

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“…And the prevalence of autoimmune hypothyroidism in childhood is an estimated 1%‐2% . The prevalence both hyperthyroidism and hypothyroidism in our cohort varied with the reported figures elsewhere for children of this age . Some methodological issues might be related to the discrepancies.…”

Section: Discussioncontrasting

confidence: 53%

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Correlation between attention‐deficit/hyperactivity disorder, its pharmacotherapy and thyroid dysfunction: A nationwide population‐based study in Taiwan

Chen

Shyu

Tsai

et al. 2018

Clinical Endocrinology

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Section: Discussioncontrasting

confidence: 53%

“…45 The prevalence both hyperthyroidism and hypothyroidism in our cohort varied with the reported figures elsewhere for children of this age. 46 Some methodological issues might be related to the discrepancies. First, race/ethnicity differences had been observed in the prevalence of thyrotoxicosis.…”

Section: Discussionmentioning

confidence: 99%

Correlation between attention‐deficit/hyperactivity disorder, its pharmacotherapy and thyroid dysfunction: A nationwide population‐based study in Taiwan

Chen

Shyu

Tsai

et al. 2018

Clinical Endocrinology

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“…Thyroid disorders have emerged as the most common endocrine disease, especially in China, and the prevalence and spectrum of thyroid disorders are increasing in the past 20 years . However, it is usually difficult to diagnose thyroid disorders in early stages due to the lack of obvious signs and symptoms .…”

Section: Introductionmentioning

confidence: 99%

Reference intervals for thyroid‐stimulating hormone and thyroid hormones using the access TSH 3rd IS method in China

Wang

et al. 2020

Clinical Laboratory Analysis

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Background:To calculate the reference intervals for thyroid-stimulating hormone (TSH) and thyroid hormones using the Access TSH 3rd IS method and evaluate the differences between age and genders in Chinese populations. Methods:This study collected 349 serum samples of healthy subjects were from Shengli Oilfield Central Hospital in China. Subjects who tested positive for thyroid peroxidase antibody or thyroglobulin antibody were excluded. Accordingly, 313 subjects were included for establishing reference intervals for the thyroid hormones.The serum concentrations of TSH, total and free thyroxine (TT4 and FT4), and total and free triiodothyronine (TT3 and FT3) were measured using the Access TSH 3rd IS method. The 2.5th and 97.5th percentiles or mean with standard deviation were calculated as the reference interval as appropriate. Results:The reference intervals for TSH, FT4, FT3, TT4, and TT3 calculated in present study were 0.61-4.16 mIU/L, 0.67-1.11 ng/dL, 2.63-4.33 pg/mL, 5.56-11.33 μg/ dL, and 0.72-1.32 ng/mL, respectively. The FT3, TT4, and TT3 levels in males were significantly higher than in females (P < .05), while TSH levels in males were significantly lower than in females (P < .05). The levels of FT3 in subjects with the age of less than 30 years were significantly higher than other groups (P < .05). Conclusion:The present study provided a valid basis for the reference intervals for TSH, FT4, FT3, TT4, and TT3 in Chinese populations. In addition, this present study indicated that age and gender should be considered in diagnostic evaluation of thyroid diseases. K E Y W O R D SAccess TSH 3rd IS method, Chinese populations, reference intervals, thyroid hormones, thyroid-stimulating hormone

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“…In addition, thyroid hormone production is decreased, while a TSHR up-regulation was detected in follicular thyroid cancer cells after exposure for 24 h to a random positioning machine (RPM) [12] - a device designed to simulate microgravity conditions [13, 14]. As thyroid hormones produced by the thyroid gland are influencing the function of nearly every cell and organ of the human body [15, 16], thyroid cells cultured under microgravity justify a thorough investigation. Therefore, the research was extended to normal thyrocytes.…”

Section: Introductionmentioning

confidence: 99%

Cytokine Release and Focal Adhesion Proteins in Normal Thyroid Cells Cultured on the Random Positioning Machine

Warnke

Pietsch

Kopp

et al. 2017

Cell Physiol Biochem

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Background/Aims: Spaceflight impacts on the function of the thyroid gland in vivo. In vitro normal and malignant thyrocytes assemble in part to multicellular spheroids (MCS) after exposure to the random positioning machine (RPM), while a number of cells remain adherent (AD). We aim to elucidate possible differences between AD and MCS cells compared to 1g-controls of normal human thyroid cells. Methods: Cells of the human follicular epithelial thyroid cell line Nthy-ori 3-1 were incubated for up to 72 h on the RPM. Afterwards, they were investigated by phase-contrast microscopy, quantitative real-time PCR and by determination of cytokines released in their supernatants. Results: A significant up-regulation of IL6, IL8 and CCL2 gene expression was found after a 4h RPM-exposure, when the whole population was still growing adherently. MCS and AD cells were detected after 24 h on the RPM. At this time, a significantly reduced gene expression in MCS compared to 1g-controls was visible for IL6, IL8, FN1, ITGB1, LAMA1, CCL2, and TLN1. After a 72 h RPM-exposure, IL-6, IL-8, and TIMP-1 secretion rates were increased significantly. Conclusion: Normal thyrocytes form MCS within 24 h. Cytokines seem to be involved in the initiation of MCS formation via focal adhesion proteins.

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Thyroid Disorders in Children and Adolescents

Cited by 175 publications

References 76 publications

Correlation between attention‐deficit/hyperactivity disorder, its pharmacotherapy and thyroid dysfunction: A nationwide population‐based study in Taiwan

Correlation between attention‐deficit/hyperactivity disorder, its pharmacotherapy and thyroid dysfunction: A nationwide population‐based study in Taiwan

Reference intervals for thyroid‐stimulating hormone and thyroid hormones using the access TSH 3rd IS method in China

Cytokine Release and Focal Adhesion Proteins in Normal Thyroid Cells Cultured on the Random Positioning Machine

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