Thymus and Lymph Node Cell Cd4+and Cd8+marker Expression and Their Angiogenic Activity of Offspring of Salbutamol-Treated Pregnant C3h Mice

Kamiński, Paweł; Skopińska-Różewska, Ewa; Wasik, M; Bany, Janusz; Barcz, Ewa; Sommer, Ewa; Marianowski, L

doi:10.1006/phrs.1999.0564

Cited by 2 publications

(1 citation statement)

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“…Consistent with these results are other in vivo studies showing that administration of the nonselective ␤ -agonist isoproterenol to mice results in reduced thymus weight and thymocyte number [50] and that an increased thymocyte apoptotic index is observed in pigs after prolonged (2 months) feeding with anabolic doses of the ␤ 2 -agonist clenbuterol [51] . Also decreased thymus weight and cellularity are observed in the thymus of the offspring of mice treated with the ␤ 2 -agonist salbulamol [52] . These findings are in line with the in vitro immunosuppressive and proapoptotic effects of NA and ␤ 2 -agonists.…”

Section: Effects Of Sympathetic Mediators On Thymic Cellsmentioning

confidence: 98%

The Role of the Sympathetic Nervous System in the Thymus in Health and Disease

Roggero

Besedovsky²,

Rey³

2011

Neuroimmunomodulation

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The existence of a network of immunoneuroendocrine interactions that results in the reciprocal modulation of the classical functions of each system is well established at present. Most of the evidence derives from studies on secondary lymphoid organs, such as the spleen and lymph nodes. In this article, several aspects relevant to understand the role of the sympathetic nervous system in the establishment of these interactions in the thymus are discussed. At present, the sympathetic innervation of the thymus, the expression of adrenergic receptors in thymic cells, particularly of β-adrenergic receptors, and the effect of sympathetic neurotransmitters, although mainly derived from in vitro or pharmacological studies, seem to be relatively well studied. However, other aspects, such as the relevance that immune-sympathetic interactions at the thymic level may have for certain diseases, specially autoimmune or other diseases that primarily involve the activation of the immune system, as well as how the integration of sympathetic and hormonal signals at local levels may affect thymic functions, certainly deserve further investigation.

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Section: Effects Of Sympathetic Mediators On Thymic Cellsmentioning

confidence: 98%