Thymosin beta 4 stimulates laminin-5 production independent of TGF-beta

Sosne, Gabriel; Xu, Ling; Prach, L.M.; Mrock, Linda; Kleinman, Hynda K.; Letterio, John J.; Hazlett, Linda D.; Kurpakus-Wheater, Michelle

doi:10.1016/j.yexcr.2003.09.022

Cited by 67 publications

(54 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the other genes up-regulated by Tb4 are cytoskeletal-related proteins, including myosin IIA, a-actinin, tropomyosin, talin, a 5 -integrin, vinculin [84] and zyxin [85], extracellular matrix (ECM) components such as laminin-5 [86] and matrix metalloproteinases, which degrade components of ECM [41,87] consistent with a role for Tb4 in co-ordinating the necessary changes to the cytoskeleton and ECM which are required to effect cell migration.…”

Section: Does Endogenous Tb4 Stimulate Angiogenesis?mentioning

confidence: 82%

Thymosin β4 and angiogenesis: modes of action and therapeutic potential

Smart¹,

Rossdeutsch²,

Riley³

2007

Angiogenesis

View full text Add to dashboard Cite

show abstract

Section: Does Endogenous Tb4 Stimulate Angiogenesis?mentioning

confidence: 82%

Thymosin β4 and angiogenesis: modes of action and therapeutic potential

Smart¹,

Rossdeutsch²,

Riley³

2007

Angiogenesis

View full text Add to dashboard Cite

show abstract

“…A recent study showed that thymosin β4 promotes laminin-5 (LM-5) expression (Sosne et al, 2004). Using gene expression analysis with human corneal epithelial cells treated with thymosin β4, the laminin-5 γ2 chain was increased by more than 2-fold over untreated cells.…”

Section: Discussionmentioning

confidence: 97%

“…It interacts with laminin-6 and -7 to form a stable association with the basement membrane structure (Carter et al, 1991;Kallunki et al, 1992;Ljubimov et al, 1995;Champliaud et al, 1996). LM-5 is induced by thymosin β4 in the cornea (Sosne et al, 2004). LM-5 is expressed by migrating keratinocytes and is expressed in hair follicles (Chuang et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Over-expression of thymosin beta4 promotes abnormal tooth development and stimulation of hair growth

Jae¹,

Philp

Lee³

et al. 2010

Int. J. Dev. Biol.

View full text Add to dashboard Cite

Thymosin β β β β β4 has multi-functional roles in cell physiology. It accelerates wound healing, hair growth and angiogenesis, and increases laminin-5 expression in corneal epithelium. Furthermore, thymosin β β β β β4 stimulates tumor growth and metastasis by induction of cell migration and vascular endothelial growth factor-mediated angiogenesis. Using a construct on the skinspecific keratin-5 promoter, we have developed thymosin β β β β β4 over-expressing transgenic mice to further study its functional roles. Thymosin β β β β β4 in adult skin and in embryonic stages of the transgenic mouse was analyzed by both Western blot and immunohistochemistry. The overexpression of thymosin β β β β β4 was observed especially around hair follicles and in the teeth in the transgenic mice. We examined the phenotype of the thymosin β β β β β4 over-expressing mice. Hair growth was accelerated. In addition, the transgenic mice had abnormally-shaped white teeth and dull incisors. We found that the expression of laminin-5 was up-regulated in the skin of the transgenic mice. We conclude that thymosin β β β β β4 has an important physiological role in hair growth and in tooth development.

show abstract

“…Besides, it is also reported that Tβ4 modulates the matrix environment by regulating laminin-5 and matrix metallopeptidases, which promotes the migration of endothelial cells to the wound site [21,22]. Tβ4 and its cleaved form, AcSDKP, were shown to inhibit fibrosis in liver and kidney by inducing the deactivation of transforming growth factor-β signaling and impairing cell proliferation in extracellular matrix [23].…”

Section: Discussionmentioning

confidence: 99%

Local Thymosin β4 Gel Injection Prevents Esophageal Stricture after Circumferential Endoscopic Submucosal Dissection in a Porcine Model

Wang

Shuai

Tang

et al. 2018

Dig Dis

View full text Add to dashboard Cite

Background: Endoscopic submucosal dissection (ESD) is widely used in the treatment of early esophageal cancer. However, the incidence of postoperative esophageal stricture is relatively high, especially after full circumferential ESD. Previous studies have shown that thymosin β4 (Tβ4) has anti-fibrotic activity and prevents scar formation. In this study, we investigated the safety and therapeutic effect of Tβ4 injection in preventing esophageal stricture after circumferential ESD in a porcine model. Methods: A total of 8 Bama pigs underwent esophageal circumferential ESD under anesthesia (n = 4 for experimental and control group). Local injection of Tβ4 gel was administered in the experimental group. Follow-up endoscopy was conducted, and balloon dilation (EBD) was performed to prevent the occurrence of esophageal stricture. Results: Esophageal stricture developed after circumferential ESD in all pigs. Local Tβ4 gel injection has shortened resolution of the stricture (p = 0.012) and was associated with a lesser number of EBD sessions (p = 0.002). The severity of esophageal stricture was milder in the experimental group (p = 0.046 vs. control group). No adverse events occurred in the study. Conclusions: Local Tβ4 gel injection appeared to be safe and effective for the prevention of esophageal stricture after circumferential ESD in a porcine model.

show abstract

Thymosin beta 4 stimulates laminin-5 production independent of TGF-beta

Cited by 67 publications

References 37 publications

Thymosin β4 and angiogenesis: modes of action and therapeutic potential

Thymosin β4 and angiogenesis: modes of action and therapeutic potential

Over-expression of thymosin beta4 promotes abnormal tooth development and stimulation of hair growth

Local Thymosin β4 Gel Injection Prevents Esophageal Stricture after Circumferential Endoscopic Submucosal Dissection in a Porcine Model

Contact Info

Product

Resources

About