Thymoquinone in liposomes: a study of loading efficiency and biological activity towards breast cancer

Odeh, Fadwa; Ismail, Said I.; Abu-Dahab, Rana; Mahmoud, Ismail Sami; Bawab, Abeer Al

doi:10.3109/10717544.2012.727500

Cited by 166 publications

(174 citation statements)

References 8 publications

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“…To ensure the presence of TQ inside the encapsulated nanoparticles the absorbance of nanoparticles were measured by UV/Vis Spectrophotometer (Perkin Elmer, LAMBDA 1050,USA) at 330 nm [38]. The hydrodynamic size and zeta potential were measured by DLS analysis (Delsa™ Nano C, Beckman Coulter, USA).…”

Section: Physico-chemical Characterization Of Tq-npsmentioning

confidence: 99%

PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a

et al. 2015

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Section: Physico-chemical Characterization Of Tq-npsmentioning

confidence: 99%

PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a

et al. 2015

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“…Thymoquinone (TQ) is a potentially active compound of black cumin seeds (Nigella sativa L) 1 . TQ have biological activity as an antioxidant, antimicrobial, anticancer and antiinflammatory effect 2 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Activity Analysis of 3-(10-Bromodecyl)-5-isopropyl-2-methyl-1,4-benzoquinone: In-silico Approach

Setyatama¹,

Ulfa²,

Okamoto³

2018

Proceedings of the 1st International Conference in One Health (ICOH 2017)

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The 3-(10-bromodecyl)-5-isopropyl-2-methyl-1,4-benzoquinone (1) have been synthesized and structurally characterized by mass spectrometer (LC-MS), FT-IR, 1 H-NMR and 13 C-NMR spectra. The synthesis was carried out by refluxed Thymoquinone (TQ) with bromoundecanoic acid in the presence of acetonitrile:water (2:1 v/v) for 1.5 h. Purification of the products was conducted by open-column chromatography. Determination of product is mainly observed from C-Br stretching at 562-563 cm -1 by FT-IRand the chemical shift at δ= 3.4 ppm ( 1 H-NMR) and 33-34 ppm ( 13 C-NMR). In addition, δ = 1.38-3.05 ppm ( 1 H-NMR) and 21-32 ppm ( 13 C-NMR) considered as aliphatic alkane which substituted at C-6 onThymoquinone ring. Analysis using LC-MS showed the molecular weight of 1is 382.96 g/mol. The yield of 1is 12.09% as brownishyellow liquid. Activity test of 1against the cytochrome protein (CYP) as macromolecule model revealed a good fit with IC 50 1.23 mg/mL lower than TQ (36.11 mg/mL). It is showed that compound 1 exhibit anticancer activity better than TQ.

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“…The EE values for the FDG loaded NP was much higher due to the increased concentration of the bioactive compounds due to freeze drying. Alam et al [28] reported 63% for TQ-chitosin NP whereas 90% was reported for TQ-liposome NP [29]. Many factors influences the control and regulation of the EE such as the: entrapped material, polymer molecular weight, and lactide: glycolide ratio [30] [31] [32], likewise the interaction between the hydroxyl group of the active compound and carboxyl group of the PLGA.…”

Section: Entrapment Efficiencymentioning

confidence: 99%

Physicochemical Properties and Control Release of Aloe Vera (Aloe barbadensis Miller) Bioactive Loaded Poly (Lactic Co-Glycolide Acid) Synthesized Nanoparticles

Kassama¹,

Misir²

2017

ACES

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Nano-encapsulation is a platform which offers a promising application for control release and the delivery of drugs in pharmaceuticals and antioxidant/antimicrobial in food systems. Poly (lactic-co-glycolide acid) (PLGA) is a biodegradable and biocompatible co-polymer of lactic acid and glycolic acid which is used for synthesizing food based polymeric nanoparticles (NP). The aim of this study was to evaluate the morphological and physicochemical properties and the controlled release of bioactive components derived from Aloe vera gel loaded PLGA NP. The results shows the mean hydrodynamic diameter of the unloaded NP is 103 nm which is significantly (p < 0.01) smaller than the loaded freeze dried powered gel (FDG) (147 nm) and liquid gel (LG) (221 nm) and the particle size distribution given by the Poly-dispersity Index were 0.2, 0.2 and 0.3, respectively. The zeta potential for unloaded, FDG and LG NP were ±60, ±28 and ±22 mV, respectively, hence were electrokinetically stable NP. No significant (p > 0.05) inhibition of the antioxidant potential was observed with loaded NP. The entrapment efficiency for the FDG synthesized was 87%, and the burst effect was observed after 4 h as a result of the encapsulation effect. The release kinetics of bioactive is govern by the combination of mass diffusion and capillary action.

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Thymoquinone in liposomes: a study of loading efficiency and biological activity towards breast cancer

Cited by 166 publications

References 8 publications

PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a

PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a

Synthesis and Activity Analysis of 3-(10-Bromodecyl)-5-isopropyl-2-methyl-1,4-benzoquinone: In-silico Approach

Physicochemical Properties and Control Release of Aloe Vera (Aloe barbadensis Miller) Bioactive Loaded Poly (Lactic Co-Glycolide Acid) Synthesized Nanoparticles

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