Thymoquinone improves the kidney and liver changes induced by chronic cyclosporine A treatment and acute renal ischaemia/reperfusion in rats

Farag, Mahmoud M.; Ahmed, Ghada O; Shehata, Rowaida R; Kazem, Amani

doi:10.1111/jphp.12363

Cited by 46 publications

(35 citation statements)

References 31 publications

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“…Various studies have shown that TQ has protective effects against I/R injury to the several organs such as kidneys, lungs, and liver in different experimental models [38, 39]. The effect of TQ on hepatic and renal changes induced by renal I/R in the rats was investigated.…”

Section: Resultsmentioning

confidence: 99%

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An Overview on Renoprotective Effects of Thymoquinone

et al. 2018

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Background: Kidneys as vital organs remove waste material from blood. Additionally, they may also have a role in the electrolyte balance, regulation of blood pressure, and red blood cell genesis. Kidney diseases may be caused by several factors such as ischemia/reperfusion injury, diabetes, and nephrotoxic agents. Oxidative stress and inflammation are involved in the pathogenesis and progression of kidney diseases. Traditionally, natural antioxidants are used for treatment of renal failure in various countries. Summary: People usually select natural antioxidants since they have an opinion that herbal medicine has not any important side effects. Nigella sativa is a flavoring herb that is widely used as a condiment and as a remedy for many disorders. Thymoquinone (TQ), the most important component of black seeds, mainly oil, is considered as an active agent responsible for a lot of the seed’s useful effects. This review describes the protective roles and related mechanisms of TQ against renal disorders. The search terms, including TQ, antioxidant, renal ischemia-reperfusion, diabetic nephropathy, and nephrotoxic agent were searched in scientific databases. TQ showed anti-inflammatory and antioxidant properties in animal and in vitro models of several renal diseases caused by inflammation and oxidative stress. Key Messages: Experimental studies have shown beneficial effects of TQ against renal diseases; however, well-designed clinical trials in humans are required to confirm these effects.

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Section: Resultsmentioning

confidence: 99%

“…Farag et al [38] investigated the effects of chronic cyclosporine A (CsA) treatment and acute renal I/R on the liver and kidney in rats treated with TQ. TQ treatment (10 mg/kg per day) decreased serum indicators back to control levels and improved CsA-induced renal and hepatic histopathological alterations.…”

Section: Resultsmentioning

confidence: 99%

An Overview on Renoprotective Effects of Thymoquinone

et al. 2018

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“…Hosseinzadeh et al showed that TQ has protective effects on lipid peroxidation after IRI in rat hippocampus (25). In various experimental studies, TQ's protective effects including antioxidant and free radical scavenging activity were shown (15)(16)(17). Additionally, TQ inhibits the some inflammatory mediators' production (26)(27)(28)(29)(30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

“…Black seed is an annual flowering plant native to some areas like Mediterranean countries (13). 1963 was the year thymoquinone was first extracted as the main active ingredient of NS (14) and it was described as a potent superoxide scavenger and free radical (15)(16)(17). However, NS also has an antioxidative effect on the spinal cord, heart and renal tissue IRI (18)(19)(20).…”

Section: öZetmentioning

confidence: 99%

Assessment of the Effects of Levosimendan and Nigella Sativa on Myocardial Ischemia Reperfusion Injury in Rats

2018

GMJ

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Objective: Ischemia-reperfusion injury is a chain of events put in place by tissue ischemia. Reperfusion following the damage of cell causes an active inflammatory response. In our research we tried to evaluate the protective effect of Levosimendan and Nigella Sativa on myocardial ischemia-reperfusion injury in rats. Methods: We included twenty-four Wistar albino rats in our research. The rats were randomly divided into four experimental groups. The coronary arteries of rats in Group C (control group) were not occluded or reperfused. Left anterior descending coronary artery was ligated for 30 min to perform myocardial IR and then reperfused for 2 h in the IR (IR), IR-Levosimendan (24µg/kg) (IRL) and IR-Nigella Sativa (0.2 mL/kg) (IRNS) group.

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“…7 Since its rst extraction in 1963, 8 thymoquinone has been shown to act as a potent free radical and superoxide scavenger. [9][10][11] In addition, it has been shown to have anti-inammatory properties in vivo and vitro studies. 12,13 It has also been shown to exert positive effects on DOX-induced nephropathy and ischaemia-reperfusion-induced kidney injury in rats.…”

Section: Apoementioning

confidence: 99%

Thymoquinone reduces kidney damage in apolipoprotein E-deficient mice fed a high-cholesterol diet

et al. 2017

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Thymoquinone improves the kidney and liver changes induced by chronic cyclosporine A treatment and acute renal ischaemia/reperfusion in rats

Abstract: Kidney and liver injury due to CsA or renal I/R can be significantly reduced by TQ, which resets the oxidant/antioxidant balance of the affected organs through scavenging free radicals and antilipoperoxidative effects.

Cited by 46 publications

References 31 publications

An Overview on Renoprotective Effects of Thymoquinone

An Overview on Renoprotective Effects of Thymoquinone

Assessment of the Effects of Levosimendan and Nigella Sativa on Myocardial Ischemia Reperfusion Injury in Rats

Thymoquinone reduces kidney damage in apolipoprotein E-deficient mice fed a high-cholesterol diet

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