2012
DOI: 10.1055/s-0032-1322611 View full text |Buy / Rent full text
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Abstract: Completeness of resection and Masaoka-Koga stage were significant prognostic factors. Multidisciplinary treatments of patients with thymoma or thymic carcinoma result in good patient care, and global efforts with larger number of patients are needed to elucidate more about the biology, diagnosis, and treatment of these tumors.

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“…With regards to WHO classification, Fibrinogen serum levels were highest in TCs, and lowest in AB thymomas and MNT. TCs are characterized by more aggressive tumor behavior, higher recurrence rates, and worse outcome, while AB thymomas and MNT are associated with a more indolent course and favorable outcome [ 8 , 9 , 30 ]. Similar associations between elevated pretreatment Fibrinogen serum levels and advanced disease stage and worse outcome have been reported in various other malignancies, including nasopharyngeal carcinoma, malignant pleura mesothelioma, ovarian cancer, endometrial cancer, and lymphomas [ 31 35 ].…”
Section: Discussionmentioning
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“…With regards to WHO classification, Fibrinogen serum levels were highest in TCs, and lowest in AB thymomas and MNT. TCs are characterized by more aggressive tumor behavior, higher recurrence rates, and worse outcome, while AB thymomas and MNT are associated with a more indolent course and favorable outcome [ 8 , 9 , 30 ]. Similar associations between elevated pretreatment Fibrinogen serum levels and advanced disease stage and worse outcome have been reported in various other malignancies, including nasopharyngeal carcinoma, malignant pleura mesothelioma, ovarian cancer, endometrial cancer, and lymphomas [ 31 35 ].…”
Section: Discussionmentioning
“…For advanced TETs, the mainstay of treatment is surgical tumor resection combined with multimodal therapy, which results in excellent 5- and 10-year overall survival (OS) rates of 96.5% and 90.9%, respectively [ 7 , 8 ]. However, up to 30% of cases exhibit tumor recurrence, potentially even decades after initial therapy, necessitating lifelong follow-up mandatory [ 9 , 10 ].…”
Section: Introductionmentioning
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“…TETs are clinically staged according to the Masaoka-Koga staging system based on their level of invasiveness [ 2 ]. TCs usually present with more aggressive tumor behavior, advanced tumor stages and consequently with worse overall survival (OS) and freedom from recurrence (FFR) compared to thymomas [ 3 5 ]. TNETs comprise less than 5% of all TETs and are characterized by high biologic aggressiveness and poor prognosis due to high rates of recurrences and tumor related deaths [ 6 , 7 ].…”
Section: Introductionmentioning
“…Tumor recurrence rates of 17%, 28% and 38% for patients with thymomas, TCs and TNETs were described, respectively [ 4 , 7 , 9 ] Surgical resection of recurrences was proposed as the mainstay of treatment and was associated with prolonged survival for patients [ 10 , 11 ] In particular, survival of patients after complete re-resection of tumor recurrence was comparable to patients not experiencing recurrences and was significantly improved compared to patients undergoing non-surgical treatment regimes for recurrence [ 12 , 13 ] So far no serum biomarkers have been established for diagnosis and screening of TETs to identify those patients with higher risk for tumor recurrence. Consequently lifelong surveillance with repeated chest computed tomography (CT) with the inherent unwanted (carcinogenic) effects of radiation exposure is recommended for patients with TETs [ 5 , 14 , 15 ]. Sensitive and affordable molecular biomarkers for detection of TETs and their recurrences are needed [ 16 ].…”
Section: Introductionmentioning