Thymoma: inter-relationships among World Health Organization histology, Masaoka staging and myasthenia gravis and their independent prognostic significance: a single-centre experience

Ruffini, Enrico; Filosso, Pier Luigi; Mossetti, C; Bruna, Maria Cristina; Novero, Domenico; Lista, Patrizia; Casadio, Caterina; Oliaro, A

doi:10.1016/j.ejcts.2010.09.042

Cited by 74 publications

(71 citation statements)

References 24 publications

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“…Other studies did not find differences in survival between type B3 thymoma or atypical thymoma and other thymomas 45,55 and failed to show an association of WHO or proposed Suster and Moran classification with outcome. 45,56,57 These varying results might have been, at least in part, due to interobserver variation. Indeed, studies reported an only fair to moderate reproducibility of the 2004 WHO classification of TET, with j values ranging between 0.39 and 0.53 or an overall concordance rate of 63% to 70%.…”

Section: Staging Is Prognostically Superior To Histomorphologic Classmentioning

confidence: 98%

Evolution of Classification of Thymic Epithelial Tumors in the Era of Dr Thomas V. Colby

Roden¹

2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Numerous histomorphologic and staging classifications of thymic epithelial tumors (TETs) have been proposed during the last century, suggesting that the classification of these tumors is challenging and controversial. Difficulties of classifying TETs include various combinations of epithelial cells and lymphocytes and the paucity of these tumors. The prognostic significance, specifically of the histomorphologic classifications, has been debated. Early classifications were also challenged by the uncertainty of the neoplastic component(s) of the tumor.Objective.-To discuss the evolution of the histomorphologic classification and the staging system of TET. Controversies and problems of some classifications and their importance for therapeutic management and prognosis will be reviewed. Classifications that incorporated new concepts and approaches at the time or outcome studies will be highlighted. Current classifications will be discussed and the staging system that was recently proposed for the upcoming eighth American Joint Committee on Cancer staging will be described.Data Sources.-Search of literature database (PubMed) and current (2015) World Health Organization classification.Conclusions.-Histomorphologic and staging classifications of TET have evolved during the last century and especially during the era of Thomas V. Colby, MD. Evidence supports that the staging system has prognostic implications independent of and superior to the histomorphologic classification. Histomorphology appears to be important for biologic features of TET.

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Section: Staging Is Prognostically Superior To Histomorphologic Classmentioning

confidence: 98%

Evolution of Classification of Thymic Epithelial Tumors in the Era of Dr Thomas V. Colby

Roden¹

2017

Archives of Pathology &Amp; Laboratory Medicine

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“…Staging is the most important prognostic factor. Age, gender, and other immunological diseases are not significant [2,[6][7][8][9][10]. In the current case, there was no recurrence after one year of postoperative follow-up.…”

Section: Discussionmentioning

confidence: 77%

A Rare Thymoma Type Presenting as a Giant Intrathoracic Tumor: Lipofibroadenoma

Aydın

Şipal

Çelik

et al. 2012

EAJM

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Type B1 thymoma (lipofibroadenoma) is extremely rare. The tumor is characterized by an organoid appearance rich in lymphocytes with medullary differentiation and perivascular spaces. A twenty-threeyear-old female patient was admitted to our clinic with complaints of chest pain and dyspnea for six months. Chest computed tomography showed solid and fatty components of masses 21×7 and 5×7 cm with clear borders in the right thoracic cavity. The patient underwent a posterolateral thoracotomy in which the mass, arising from the anterior mediastinum, was resected. Histopathological examination showed that the mass was Type B1 thymoma, and the patient was presented in light of the literature. Key Words: Lipofibroadenoma, Mediastinum, Thymoma ÖzetTip B1 timoma (lipofibroadenoma) oldukça nadirdir. Tümör medül-ler farklılaşma ve perivasküler aralık ile lenfositten zengin organoid bir görünümle karakterizedir. Yirmi üç yaşında bir bayan olgu altı ay önce başlayan göğüs ağrısı ve nefes darlığı şikâyetleri ile kliniğimize başvurdu. Toraks bilgisayarlı tomografide sağ torasik kavitede düz-gün kenarlı solid ve yağ dansiteleri içeren bir kitle (21×7, 5×7 cm) görüldü. Olguya uygulanan posterolateral torakotomide anterior mediastenden kaynaklanan bir kitle tespit edilip rezeke edildi. Histopatolojik inceleme Tip B1 timoma olarak bildirilen olgu literatür bilgileri ışığında sunuldu.

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“…However, this is not definitive as the patients with thymoma also had a trend for worse outcome with induction therapy (5-year OS 57% vs. 87%; P=0.084). These subgroup analyses involving stratification of specific factors don't account for all potential confounding factors, since there is a strong correlation between Masaoka-Koga stage and histologic subtype of TETs (33). A multivariate model adjusted for these factors may have assisted in estimating the true effect of induction therapy.…”

Section: Biopsy For Patients With An Anterior Mediastinal Mass and Mymentioning

confidence: 99%

“…In our opinion, the authors could more strongly conclude the importance of stage and "downstaging" since it was the only factor that had a clear impact on outcome. WHO histology may be a surrogate for stage and analyses adjusting for stage may eliminate the importance of WHO histology as a prognostic factor (33).…”

Section: The Importance Of 'Downstaging'mentioning

confidence: 99%

Pretreatment biopsy for thymic epithelial tumors—does histology subtype matter for treatment strategy?

2016

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Thymoma: inter-relationships among World Health Organization histology, Masaoka staging and myasthenia gravis and their independent prognostic significance: a single-centre experience

Cited by 74 publications

References 24 publications

Evolution of Classification of Thymic Epithelial Tumors in the Era of Dr Thomas V. Colby

Evolution of Classification of Thymic Epithelial Tumors in the Era of Dr Thomas V. Colby

A Rare Thymoma Type Presenting as a Giant Intrathoracic Tumor: Lipofibroadenoma

Pretreatment biopsy for thymic epithelial tumors—does histology subtype matter for treatment strategy?

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