Thymoma: A Retrospective Review of 55 Cases of Thymoma Treated At a Regional Cancer Center

Arjunan, Ravi; Kurpad, Vishnu; Vimalathithan,; Prakash, .; Althaf, Syed; Kumar, Veerendra

doi:10.15406/jcpcr.2015.02.00025

Cited by 4 publications

(4 citation statements)

References 15 publications

(20 reference statements)

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“…22 Together, B2 and B3 subtypes constituted more than 80% of our patient population. In our study, Masaoka-Koga stages IIIB, IVA, and IVB constituted 60% of the patient population, with IIIB being the commonest stage, similar to previous reported studies from India 29 30 but contrary to Rathod et al where stages I to II were the commonest. 21 The sites of metastases in our cohort included pleura and lung in two patients and lung in one patient.…”

Section: Discussionsupporting

confidence: 91%

Long-Term Outcomes of Thymoma Treated at a Single Institute

Shishak,

Kataria,

Bisht

et al. 2024

South Asian J Cancer

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Introduction Thymomas are uncommon tumors that originate from epithelial cells of thymus and may have varying clinical course. Materials and Methods A retrospective review of medical records of thymoma patients treated between January 2012 and April 2022 at our institute was conducted. Results There were a total of 23 patients (12 males and 11 females) with median age of 52 years (range, 33–77 years). Eleven patients (47.8%) had associated paraneoplastic syndromes of which 10 (43.5%) had myasthenia gravis and 1 (4.3%) had pure red cell aplasia. Average maximal tumor diameter was 62 mm (28–160 mm). Masaoka-Koga stage distribution was as follows: stage I (n = 2, 8.7%), IIA (n = 4, 17.4%), IIB (n = 1, 4.3%), IIIA (n = 2, 8.7%), IIIB (n = 4, 17.4%), IVA (n = 7, 30.4%), and IVB (n = 3, 13.1%). The World Health Organization type B2 was the commonest histology (n = 12, 52.17%), followed by B3 (n =7, 30.4%), B1 (n = 2, 8.7%), AB (n = 1,4.3%), and A (n = 1, 4.3%). Six patients received neoadjuvant chemotherapy with cyclophosphamide regimen, 22 (95.6%) underwent surgery, and 1 patient received adjuvant chemotherapy. R0 resection was attained in 20 (91%) patients, R1 resection in 1 (4.5%) patient, and R2 in 1 (4.5%) patient. All operated patients underwent postoperative radiotherapy (45–60 Gy in 25–30 fractions). Four patients relapsed at a median duration of 14 months (2–26 months). At a median follow-up of 6 years, 5-year overall survival was 67.1% and 5-year progression-free survival was 66.6%. Local control at 5 years was 86.6%. Conclusion Despite majority of our patients presenting at an advanced stage, the local control rates are encouraging and reinforce multimodality approach.

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Section: Discussionsupporting

confidence: 91%

Long-Term Outcomes of Thymoma Treated at a Single Institute

Shishak,

Kataria,

Bisht

et al. 2024

South Asian J Cancer

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“…Global data have reported no sex predilection for TETs; however, the Indian studies had shown male predominance similar to the observation in the present series101415171823. Only two studies from India demonstrated a female-predominant population1316.…”

Section: Discussionsupporting

confidence: 83%

“…Its incidence in the Indian population has not been defined and in the power analysis carried out by Marchevsky et al 11, only 20 cases of thymomas were included from India. Among the Indian studies with more than 10 cases121314151617181920, Julka et al 18 had the largest sample with 71 cases (all thymomas) from the same centre; however, histomorphological spectrum was not described in this study. Except for studies by Vaideeswar et al 19 and Sundaram et al 20, none of the studies assessed the histomorphology of TET, especially thymic carcinomas.…”

Section: Discussionmentioning

confidence: 68%

Histotyping of Indian thymomas: A clinicopathologic study from north India

et al. 2019

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Background & objectives:Thymomas are rare, but most common anterior mediastinal lesions. The histomorphologic spectrum of thymic epithelial tumours (TETs) in Indian population has not been explored in depth. This study was aimed to assess the histomorphology of TETs in the Indian patients and correlate clinical parameters with pathological features.Methods:It was a retrospective study conducted in a tertiary referral hospital in north India. All morphologically confirmed cases of TETs since 2009 were included. Clinical details and histology slides were reviewed using the Modified Masaoka-Koga staging system and WHO 2015 classification. Clinicopathological correlation and survival analysis were done. A comparative review from other published Indian studies was performed.Results:A total of 219 cases of TETs (138 resections and 81 biopsies) were identified. The most common histomorphologic type was B2, and the most frequent stage was I. Types A/AB were common in older age (P<0.01). Clinically, higher stage tumours were found mostly in men (P<0.01), and these were Type B thymomas (P<0.01). Myasthenia gravis was more common in women (P<0.02) and in lower stages (P<0.05). Survival analysis revealed significant association between recurrence and tumour stage. Although thymic carcinoma was diagnosed on biopsy, no resectable case was identified.Interpretation & conclusions:Our findings showed that the thymomas in Indian patients were most commonly Stage I tumours of B2 and AB histotypes. Resected thymic carcinomas were conspicuously absent in our study. More studies need to be done to establish the frequency and biology of TETs from India.

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“…Indian studies have shown male preponderance same like in our study [5,8] . Few studies on thymoma have shown female preponderance in indian patients [9] . Thymomas are frequent in the age group of 40-60 yrs, but a wide range has been reported from <10 yrs to >80 yrs [10] .…”

Section: Discussionmentioning

confidence: 99%

A clinicopathological study of thymic neoplasms: Nine-year experience at a tertiary care hospital in western Maharashtra, India

Sidhu¹,

Kumar²,

Sengupta³

2020

Int. J. Clin. Diagn. Pathol.

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Introduction:The thymuses are quite rare neoplastic lesions arising in anterior mediastinum seen in the adults. The histological spectrum varied from the encapsulated thymoma to the thymic carcinomas. Further subtyping into various groups on the basis of morphology with immunohistological findings have gained the popularity as depicted by the latest WHO classification of thymomas. A few studies have been done to ascertain the characteristics of thymic neoplasms in Indian population. Methodology: 09 years retrospective analysis of the total 17 thymoma cases reported from year 2011 to 2019 were assessed for histomorphological features with clinical findings, age, sex and staging. Results: The commonest subtypes were of B2 and B1 types with type A, AB and B3 being rare. Mostly the cases were of low grade. Myasthenia Gravis was associated with only 02 thymomas. Conclusion:The morphological classification and staging of thymomas should be used in surgical pathology reporting.

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Thymoma: A Retrospective Review of 55 Cases of Thymoma Treated At a Regional Cancer Center

Cited by 4 publications

References 15 publications

Long-Term Outcomes of Thymoma Treated at a Single Institute

Long-Term Outcomes of Thymoma Treated at a Single Institute

Histotyping of Indian thymomas: A clinicopathologic study from north India

A clinicopathological study of thymic neoplasms: Nine-year experience at a tertiary care hospital in western Maharashtra, India

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