Thymectomy for non-thymomatous myasthenia gravis

Clinical features and impact of myasthenia gravis disease in Australian patients

“…Patients with thymectomy appeared to be more commonly in remission than those without thymectomy. There is no good data regarding the effectiveness of thymectomy in non-thymomatous MG although some observational studies suggest it is of benefit [32] and this is supported by our group.…”

Clinical features and impact of myasthenia gravis disease in Australian patients

“…Patients with thymectomy appeared to be more commonly in remission than those without thymectomy. There is no good data regarding the effectiveness of thymectomy in non-thymomatous MG although some observational studies suggest it is of benefit [32] and this is supported by our group.…”

Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial

“…15 This benefit from thymectomy persists at least for 5 years and extends beyond clinical status alone to include significant reductions in immunosuppressive medication requirements and hospitalisations for disease exacerbations. Implications of these results include revisions to formal practice parameters that had previously failed to uncover evidence to argue in favor of the procedure 3,4 and reversing trends showing a marked reduction in MG-related admissions for thymectomy after 2000. 25…”

Transsternal Thymectomy

“…28 A survey found that only 5% of experts expressed no doubt in using thymectomy in generalized MG, while more than 20% had significant reservations about recommending this procedure. 39 So far, there is no randomized trial showing definitive conclusions about the efficacy of surgical treatment for MG, but data from many class III observational studies suggest a potential benefit of thymectomy in MG. 2 The extension of thymic and fat tissue resection that allows achieving an optimal disease control is still controversial. Different surgical approaches have been proposed.…”

“…Different surgical approaches have been proposed. The transsternal way is the most commonly used because of its adequate exposure for complete fatty tissue removal, but transcervical and video-assisted approach have been successfully employed with low rates of complications and mortality, and comparable remission rates 2,38,[40][41][42][43][44].…”

Clinical features and impact of myasthenia gravis disease in Australian patients

“…Patients with thymectomy appeared to be more commonly in remission than those without thymectomy. There is no good data regarding the effectiveness of thymectomy in non-thymomatous MG although some observational studies suggest it is of benefit [32] and this is supported by our group.…”

Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial

“…15 This benefit from thymectomy persists at least for 5 years and extends beyond clinical status alone to include significant reductions in immunosuppressive medication requirements and hospitalisations for disease exacerbations. Implications of these results include revisions to formal practice parameters that had previously failed to uncover evidence to argue in favor of the procedure 3,4 and reversing trends showing a marked reduction in MG-related admissions for thymectomy after 2000. 25…”

Transsternal Thymectomy

“…28 A survey found that only 5% of experts expressed no doubt in using thymectomy in generalized MG, while more than 20% had significant reservations about recommending this procedure. 39 So far, there is no randomized trial showing definitive conclusions about the efficacy of surgical treatment for MG, but data from many class III observational studies suggest a potential benefit of thymectomy in MG. 2 The extension of thymic and fat tissue resection that allows achieving an optimal disease control is still controversial. Different surgical approaches have been proposed.…”

“…Different surgical approaches have been proposed. The transsternal way is the most commonly used because of its adequate exposure for complete fatty tissue removal, but transcervical and video-assisted approach have been successfully employed with low rates of complications and mortality, and comparable remission rates 2,38,[40][41][42][43][44].…”

Clinical features and impact of myasthenia gravis disease in Australian patients

“…Patients with thymectomy appeared to be more commonly in remission than those without thymectomy. There is no good data regarding the effectiveness of thymectomy in non-thymomatous MG although some observational studies suggest it is of benefit [32] and this is supported by our group.…”

Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial

“…15 This benefit from thymectomy persists at least for 5 years and extends beyond clinical status alone to include significant reductions in immunosuppressive medication requirements and hospitalisations for disease exacerbations. Implications of these results include revisions to formal practice parameters that had previously failed to uncover evidence to argue in favor of the procedure 3,4 and reversing trends showing a marked reduction in MG-related admissions for thymectomy after 2000. 25…”

Transsternal Thymectomy

“…28 A survey found that only 5% of experts expressed no doubt in using thymectomy in generalized MG, while more than 20% had significant reservations about recommending this procedure. 39 So far, there is no randomized trial showing definitive conclusions about the efficacy of surgical treatment for MG, but data from many class III observational studies suggest a potential benefit of thymectomy in MG. 2 The extension of thymic and fat tissue resection that allows achieving an optimal disease control is still controversial. Different surgical approaches have been proposed.…”

“…Different surgical approaches have been proposed. The transsternal way is the most commonly used because of its adequate exposure for complete fatty tissue removal, but transcervical and video-assisted approach have been successfully employed with low rates of complications and mortality, and comparable remission rates 2,38,[40][41][42][43][44].…”