Abstract:BackgroundJuvenile idiopathic arthritis (JIA) is a chronic arthritis of unknown cause with an onset before 16 years of patient age.Patients with polyarticular-course JIA (pcJIA) have risk for profound disability. Although these patients may respond to methotrexate (MTX) or biological agents approved for pcJIA, up to 30% continue to have active disease.Interleukin-6 (IL-6) is increased in the serum and synovial fluid of patients with pcJIA; IL-6 concentrations are positively correlated with the severity of join… Show more
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