Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

4
107
0
2

Year Published

2001
2001
2017
2017

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 162 publications
(113 citation statements)
references
References 23 publications
4
107
0
2
Order By: Relevance
“…Moreover, preincubation with TxAS-specific inhibitor furegrelate significantly attenuated NNK-induced TxB 2 production by nearly 75% (Po0.01) in NCI-H23 cells and 90% (Po0.01) in CRL-2066 cells. In light of the fact that the synthesis of TxA 2 can be directly reflected by the TxAS expression and activity (TxB 2 generation) (Nie et al, 2000(Nie et al, , 2004Sakai et al, 2006;Cailleteau et al, 2008), these results suggest that NNK is able to increase TxA 2 output by stimulating TxAS in lung cancer cells. It should be noted that the elevated TxA 2 level indicates that TxA 2 receptor could be highly activated, which is generally attributed to the fact that TxA 2 is a bioactive agonist that specifically interacts with its receptor on target cells to impart its biologic effects (Nie et al, 2000;Nakahata, 2008).…”
Section: High Expression Of Txas In Lung Cancer Tissues Of Smokersmentioning
confidence: 86%
See 3 more Smart Citations
“…Moreover, preincubation with TxAS-specific inhibitor furegrelate significantly attenuated NNK-induced TxB 2 production by nearly 75% (Po0.01) in NCI-H23 cells and 90% (Po0.01) in CRL-2066 cells. In light of the fact that the synthesis of TxA 2 can be directly reflected by the TxAS expression and activity (TxB 2 generation) (Nie et al, 2000(Nie et al, , 2004Sakai et al, 2006;Cailleteau et al, 2008), these results suggest that NNK is able to increase TxA 2 output by stimulating TxAS in lung cancer cells. It should be noted that the elevated TxA 2 level indicates that TxA 2 receptor could be highly activated, which is generally attributed to the fact that TxA 2 is a bioactive agonist that specifically interacts with its receptor on target cells to impart its biologic effects (Nie et al, 2000;Nakahata, 2008).…”
Section: High Expression Of Txas In Lung Cancer Tissues Of Smokersmentioning
confidence: 86%
“…In light of the fact that the synthesis of TxA 2 can be directly reflected by the TxAS expression and activity (TxB 2 generation) (Nie et al, 2000(Nie et al, , 2004Sakai et al, 2006;Cailleteau et al, 2008), these results suggest that NNK is able to increase TxA 2 output by stimulating TxAS in lung cancer cells. It should be noted that the elevated TxA 2 level indicates that TxA 2 receptor could be highly activated, which is generally attributed to the fact that TxA 2 is a bioactive agonist that specifically interacts with its receptor on target cells to impart its biologic effects (Nie et al, 2000;Nakahata, 2008). It was reported that 7 mM of NNK corresponded to the approximate amount found in one pack of cigarettes (Proulx et al, 2005), and we have observed that the effects of NNK on lung cancer proliferation reach a plateau after its concentration reaches a level of 410 mM (Li et al, 2008(Li et al, , 2010.…”
Section: High Expression Of Txas In Lung Cancer Tissues Of Smokersmentioning
confidence: 86%
See 2 more Smart Citations
“…TP agonists also induce endothelial cell migration, angiogenesis and metastasis [14] and tumor metastasis [15]. The role of TPs in tumorigenesis has emerged.…”
Section: Introductionmentioning
confidence: 99%