Thrombotic thrombocytopenic purpura in a case of dengue fever: A rare presentation

Abstract

Here, we present an unusual occurrence of thrombotic thrombocytopenic purpura (TTP) in a case of dengue fever. Both the conditions are fatal and can result in significant mortality and morbidity if left untreated. In this case, as soon as, we diagnosed the patient as having TTP, we treated her with plasma exchange therapy, steroids, and monoclonal antibodies such as rituximab. The patient responded very well to the treatment and completely recovered from neurological symptoms and laboratory parameters also normalized. Hence, timely diagnosis and starting appropriate treatment immediately are key factors for successful outcome.

Dengue fever a rare cause of thrombotic thrombocytopenic purpura: a case report

“…It is important to make the diagnosis because the mortality is very high if untreated and can be reduced with the early initiation of plasma exchange [3]. The presence of TTP in dengue viral infection is rare but has been reported in the literature [4,5].…”

Thrombotic thrombocytopenic purpura associated with dengue and chikungunya virus coinfection: case report during an epidemic period

“…Infections are important causes of immune responses in the context of iTTP 5 . Reports of TTP secondary to parvovirus B19, dengue, HIV and viral hepatitis demonstrate the potential of viral infections to act as a triggering factor of microangiopathic diathesis 6 - 9 . The present case report describes iTTP secondary to dengue and chikungunya virus coinfection in the current epidemic of arbovirus infections in a State in Northeastern Brazil.…”

Thrombotic thrombocytopenic purpura or disseminated intravascular coagulation?

“…We read the paper by Gavali et al ., concerning a case of dengue virus infection complicated with thrombotic thrombocytopenic purpura (TTP) with interest. [ 1 ] Perhaps, however, disseminated intravascular coagulation (DIC) should have been ruled out in that setting.…”